Certificate of Analysis

NAX-5055

Name: NAX-5055
Brand: Alomone Labs
SKU: N-360

Gal-B2

An Agonist of GalR1 and GalR2 Galanin Receptors

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Overview

Cat #: N-360

Alternative Name Gal-B2

Lyophilized Powder yes

Origin Synthetic

MW: 2112.6 Da

Purity: >98% (HPLC)

Effective concentration 1-100 nM.

Sequence (Sar)WTLNSAGYLLGPKKK(pal)K-NH2.

Modifications N-terminal glycine is substituted with sarcosine. Lys at position 16 is palmitoylated. C-terminal amidation.

Structure

Molecular formula C₁₀₄H₁₇₄N₂₄O₂₂.

Activity NAX-5055, a systemically active analogue of the endogenous neuropeptide galanin, is a high affinity galanin receptors ligand (K_i=3.5 nM and 51.5 nM for GalR1 and GalR2, respectively), shown to prevent seizures in mouse epilepsy model in vivo^1,2.

References-Activity

Bulaj, G. et al. (2008) J. Med. Chem. 51, 8038.
White, H.S. et al. (2009) Neurotherapeutics 6, 372.

Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Solubility Soluble in DMSO. Centrifuge all products before use (10000 x g 5 min).

Storage of solutions Up to three months at -20°C.

Our bioassay

Alomone Labs NAX-5055 activates GalR2 receptor-mediated Ca²⁺mobilization in CHO-K1-Gα16-mt-Aequorin cells.
Dose response of normalized NAX-5055 (#N-360) activation of GalR2 receptor-mediated Ca²⁺ mobilization, measured as aequorin-derived fluorescence following NAX-5055 application (EC₅₀ = 6.12 nM).

Scientific background

NAX-5055 is an active analog of the endogenous neuropeptide galanin that acts as a galanin receptor 1 (GalR1) and galanin receptor 2 (GalR2) agonist. NAX-5055 demonstrates high affinity for the receptors and was shown to prevent seizures in mouse model of epilepsy following intraperitoneal administration¹.

NAX-5055 is a systemically-active, metabolically stable galanin analog that can penetrate the blood-brain-barrier and displays a potent anticonvulsant activity^2,3.

Galanin is widely expressed throughout the central and peripheral nervous systems. Galanin receptors belong to the family of G-protein coupled receptors. Studies show that galanin and its receptors are involved in the transmission and modulation of nociception in the central nervous system, at spinal cord levels and in the brain⁴.

Target Galanin Receptors

Lyophilized Powder

For research purposes only, not for human use

Last Update: 07/05/2024

Specifications

Citations

Applications

Scientific Background

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