Overview
Neuroligin & Neurexin Antibody Explorer Kit (#AK-595) contains specific Nlgn and Nrxn antibodies. Ideal for screening purposes.
Compounds
| Product Name | Cat # | Size |
|---|---|---|
Anti-Neurexin 1α (extracellular) Antibody |
ANR-031 | 1 x 50 µl |
Neurexin 1α (extracellular) Blocking Peptide |
BLP-NR031 | 1 x 40 µg |
Anti-Neurexin 3α (extracellular) Antibody |
ANR-033 | 1 x 50 µl |
Neurexin 3α (extracellular) Blocking Peptide |
BLP-NR033 | 1 x 40 µg |
Anti-Neuroligin 1 (extracellular) Antibody |
ANR-035 | 1 x 50 µl |
Neuroligin 1 (extracellular) Blocking Peptide |
BLP-NR035 | 1 x 40 µg |
Anti-Neuroligin 2 (extracellular) Antibody |
ANR-036 | 1 x 50 µl |
Neuroligin 2 (extracellular) Blocking Peptide |
BLP-NR036 | 1 x 40 µg |
Anti-Neuroligin 3 (extracellular) Antibody |
ANR-037 | 1 x 50 µl |
Neuroligin 3 (extracellular) Blocking Peptide |
BLP-NR037 | 1 x 40 µg |
Scientific Background
Neurexins (NRXNs) are a family of transmembrane, synaptic adhesion molecules. They are largely presynaptic proteins that form a trans-synaptic cell-adhesion complex with postsynaptic neuroligins1. They are encoded by three genes (NRXN1, NRXN2 and NRXN3), each giving rise to various isoforms. The α-isoforms and β-isoforms of each neurexin are single-pass transmembrane proteins maintaining identical transmembrane and intracellular domains but having distinct extracellular domains1.
Neuroligins (NLGNs) are a family of postsynaptic cell adhesion molecules that play an important role in synaptic development and function2. Four genes encode for the different members of the neuroligin family in mammals: NLGN 1-4, which are differentially enriched in postsynaptic specializations of synapses3.
- Mosedale, M. et al. (2012) J. Biol. Chem. 287, 6350.
- Chubykin, A.A. et al. (2007) Neuron 54, 919.
- Kohl, C. et al. (2013) PLoS ONE 8, e5687.
