Recombinant, E. coli

ED₅₀ = 220 pM.

BDNF is a neurotrophic factor and binds p75^NTR as well as TrkB receptors^1,2. BDNF supports the survival of many cell types^3-8.

Sterile water at a concentration of at least 1 µg/0.1 ml. BSA (0.1 mg/ml) should be added for more diluted solutions. Centrifuge all product preparations before use (10000 x g 5 min). Repeated freezing/thawing might result in loss of activity.

Recombinant, E. coli

BDNF is a neurotrophic factor and binds p75^NTR as well as TrkB receptors^1,2. BDNF supports the survival of many cell types^3-8. proBDNF has been shown to be a pro-apoptotic ligand for sympathetic neurons⁹ expressing both p75 and sortilin, and to be involved in LTD¹⁰.

Sterile water at a concentration of at least 10 µg/ml.
Centrifuge all product preparations before use (10000 x g 5 min). Repeated freezing/thawing might result in loss of activity.

Recombinant, E. coli

0.1-10 nM

BDNF is a neurotrophic factor and binds p75^NTR as well as TrkB receptors^1,2. BDNF supports the survival of many cell types^3-8. proBDNF has been shown to be a pro-apoptotic ligand for sympathetic neurons⁹ expressing both p75 and sortilin, and to be involved in LTD¹⁰.

Sterile water at a concentration of at least 10 µg/ml. Centrifuge all product preparations before use (10000 x g 5 min). Repeated freezing/thawing might result in loss of activity.

Recombinant, E. coli

0.1-10 nM.

BDNF is a neurotrophic factor and binds p75^NTR as well as TrkB receptors^1,2. BDNF supports the survival of many cell types^3-8. proBDNF has been shown to be a pro-apoptotic ligand for sympathetic neurons⁹ expressing both p75 and sortilin, and to be involved in LTD¹⁰.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Sterile water at a concentration of at least 10 µg/ml. Centrifuge all product preparations before use (10000 x g 5 min). Repeated freezing/thawing might result in loss of activity.

Up to one week at 4°C or four-six weeks at -70°C.

Recombinant, E. coli

0.2 nM.

BDNF is a neurotrophic factor and binds p75^NTR as well as TrkB receptors^1,2. BDNF supports the survival of many cell types^3-8. proBDNF has been shown to be a pro-apoptotic ligand for sympathetic neurons⁹ expressing both p75 and sortilin, and to be involved in LTD¹⁰.

Sterile water at a concentration of at least 10 µg/ml. Centrifuge all product preparations before use (10000 x g 5 min). Repeated freezing/thawing might result in loss of activity.

Recombinant, E. coli

0.2 nM.

BDNF is a neurotrophic factor and binds p75^NTR as well as TrkB receptors^1,2. BDNF supports the survival of many cell types^3-8. proBDNF has been shown to be a pro-apoptotic ligand for sympathetic neurons⁹ expressing both p75 and sortilin, and to be involved in LTD¹⁰.

Sterile water at a concentration of at least 10 µg/ml.
Centrifuge all product preparations before use (10000 x g 5 min). Repeated freezing/thawing might result in loss of activity.

Recombinant, E. coli

Cardiotrophin-1 is a member of the neuropoietic cytokine family which enhances the survival of ciliary and dopaminergic neurons through the interaction with the gp130 receptor. Cardiotrophin-1 induces cardiac myocyte hypertrophy and has been shown to promote the survival of both embryonic and neonatal rat ventricular muscle cells^1-3.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Sterile water at a concentration of at least 1 µg/0.1 ml. BSA (0.1 mg/ml) should be added for more diluted solutions. Centrifuge all product preparations before use (10000 x g 5 min). Repeated freezing/thawing might result in loss of activity.

Up to one week at 4°C or four-six weeks at -70°C.

Recombinant, E. coli

EC₅₀ ~2.2 pM.

CNTF is a potent neurotrophic factor that was originally characterized as a survival factor for chick ciliary neurons. CNTF supports growth and survival of DRG, motor and sympathetic neurons^1-4.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Sterile water at a concentration of at least 1 μg/0.1 ml. BSA (0.1 mg/ml) should be added for more diluted solutions. Centrifuge all product preparations before use (10000 x g 5 min). Repeated freezing/thawing might result in loss of activity.

Up to one week at 4°C or four-six weeks at -70°C.

Recombinant, E. coli

EC₅₀ = ~17 pM.

FGF-basic is a heparin binding growth factor which stimulates the proliferation of a wide variety of cells, including mesenchymal, neuroectodermal, endothelial, and smooth muscle cells, among many others. FGF-basic also induces neuronal and glial differentiation, survival and regeneration^1-4.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Sterile water at a concentration of at least 1 µg/0.1 ml.
BSA (0.1 mg/ml) should be added for more diluted solutions. Centrifuge all product preparations before use (10000 x g 5 min). Repeated freezing/thawing might result in loss of activity.

Up to one week at 4°C or four-six weeks at -70°C.

Recombinant, E. coli

GDNF enhances survival and differentiation of dopaminergic neurons. It is also a potent survival factor for motor neurons^1-3.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Sterile water at a concentration of at least 1 µg/0.1 ml.
Centrifuge all product preparations before use (10000 x g 5 min). Repeated freezing/thawing might result in loss of activity.

Up to one week at 4°C or four-six weeks at -70°C.

Recombinant, E. coli

EC₅₀ = ~10 pM.

LIF is a lymphoid factor which promotes long-term maintenance of embryonic stem cells by suppressing spontaneous differentiation. LIF regulates cholinergic, peptidergic and noradrenergic properties of sympathetic neurons and rescues sensory and motor neurons from death. LIF also promotes differentiation of O-2A astrocytes^1-4.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Sterile water at a concentration of at least 1 µg/0.1 ml.
BSA (0.1 mg/ml) should be added for more diluted solutions. Centrifuge all product preparations before use (10000 x g 5 min). Repeated freezing/thawing might result in loss of activity.

Up to one week at 4°C or four-six weeks at -70°C.

Recombinant, E. coli

NT-3 is involved in many biological outcomes including strengthening synaptic connections to motoneurons¹ and serving as an anti-inflammatory factor to suppress microglial activation² among many other cellular functions. NT-3 biological effects are mediated by two receptors: TrkC, which is specific for NT-3 and p75^NTR, which binds all neurotrophins³.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Sterile water at a concentration of at least 1 μg/0.1 ml. BSA (0.1 mg/ml) should be added for more diluted solutions. Centrifuge all product preparations before use (10000 x g 5 min). Repeated freezing/thawing might result in loss of activity.

Up to one week at 4°C or four-six weeks at -70°C.

Recombinant, E. coli

NT-4 is involved in many biological outcomes including promoting dendritic outgrowth and Ca²⁺ currents in cultured mesencephalic dopamine neurons¹, promoting growth and remodeling of adult motor neuron innervation². The biological effects of NT-4 are mediated by two receptors: TrkB which is specific for NT-4 and BDNF, and p75^NTR which binds all the neurotrophins³.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Sterile water at a concentration of at least 1 µg/0.1 ml.
BSA (0.1 mg/ml) should be added for more diluted solutions. Centrifuge all product preparations before use (10000 x g 5 min). Repeated freezing/thawing might result in loss of activity.

Up to one week at 4°C or four-six weeks at -70°C.

Recombinant, E. coli

EC₅₀ = 0.4 nM.

NGF is purified in three forms: the 7S, 2.5S and β. The biologically active subunit is the β, which is a 26 kDa. dimer composed of two identical chains held together by hydrophobic interactions¹. NGF has been shown to regulate neuronal survival, development, function and plasticity².

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Sterile water, DMEM at a concentration of at least 10 µg/ml. Centrifuge all product preparations before use (10000 x g 5 min). Repeated freezing/thawing might result in loss of activity.

Up to one week at 4°C or four-six weeks at -70°C.

Native protein isolated from mouse submaxillary glands.

EC₅₀ = 0.7 nM.

NGF is purified in three forms: the 7S, 2.5S and β. The 2.5S form is 9 amino acids shorter than the β form because of proteolysis that occurs during the purification process¹. NGF has been shown to regulate neuronal survival, development, function and plasticity². The biological effects of NGF are mediated by two receptors: TrkA, which is specific for NGF, and p75^NTR, which binds all the neurotrophins³.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Sterile water, DMEM at a concentration of at least 10 μg/ml. Centrifuge all product preparations before use (10000 x g 5 min). Repeated freezing/thawing might result in loss of activity.

Up to one week at 4°C or four-six weeks at -70°C.

Native protein isolated from mouse submaxillary glands.

EC₅₀ = 0.5 nM.

NGF is purified in three forms: the 7S, 2.5S and β. The 2.5S form is 9 amino acids shorter than the β form because of proteolysis that occurs during the purification process¹. NGF has been shown to regulate neuronal survival, development, function and plasticity². The biological effects of NGF are mediated by two receptors: TrkA, which is specific for NGF, and p75^NTR, which binds all the neurotrophins³.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Sterile water, DMEM at a concentration of at least 10 µg/ml. Centrifuge all product preparations before use (10000 x g 5 min). Repeated freezing/thawing might result in loss of activity.

Up to one week at 4°C or four-six weeks at -70°C.

Native protein isolated from mouse submaxillary glands.

EC₅₀ = 0.2 nM.

NGF is purified in three forms: the 7S, 2.5S and β. The 7S 130 kDa form occurs naturally in mouse submaxillary glands and is a multimeric protein composed of two α, one β and two γ subunits. The biologically active subunit is the β, which is a 26 kDa dimer composed of two identical chains held together by hydrophobic interactions. The α chain stabilizes the 7S complex and binds two zinc ions per 7S complex as a cofactor at the β-γ interface. The γ chain is an arginine specific protease, it may also have plasminongen activator activity as well as mitogenic activity for chick embryo fibroblasts^1,2.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Sterile water, DMEM at a concentration of at least 10 µg/ml. Centrifuge all product preparations before use (10000 x g 5 min). Repeated freezing/thawing might result in loss of activity.

Up to one week at 4°C or four-six weeks at -70°C.

Recombinant, E. coli

proNGF is the preferred ligand of p75^{NTR 1}. In contrast to its mature form proNGF induces apoptosis via p75^{NTR 1}, but can also mediate cell survival in DRGs².

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Sterile water, DMEM at a concentration of at least 10 µg/ml. Centrifuge all product preparations before use (10000 x g 5 min). Repeated freezing/thawing might result in loss of activity.

Up to one week at 4°C or four-six weeks at -70°C.

Recombinant, E. coli

0.4-4 nM.

proNGF is the preferred ligand of p75^NTR 1. In contrast to its mature form proNGF induces apoptosis via p75^NTR 1, but can also mediate cell survival in DRGs².

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Sterile water, DMEM at a concentration of at least 10 µg/ml. Centrifuge all product preparations before use (10000 x g 5 min). Repeated freezing/thawing might result in loss of activity.

Up to one week at 4°C or four-six weeks at -70°C.

Recombinant, E. coli

0.4 - 4 nM.

proNGF is the preferred ligand of p75^{NTR 1}. In contrast to its mature form proNGF induces apoptosis via p75^{NTR 1}, but can also mediate cell survival in DRGs².

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Sterile water, DMEM at a concentration of at least 10 µg/ml. Centrifuge all product preparations before use (10000 x g 5 min). Repeated freezing/thawing might result in loss of activity.

Up to one week at 4°C or four-six weeks at -70°C.

Recombinant, E. coli

0.4 - 4 nM.

proNGF is the preferred ligand of p75^{NTR 1}. In contrast to its mature form proNGF induces apoptosis via p75^{NTR 1}, but can also mediate cell survival in DRGs².

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Sterile water, DMEM at a concentration of at least 10 µg/ml. Centrifuge all product preparations before use (10000 x g 5 min). Repeated freezing/thawing might result in loss of activity.

Up to one week at 4°C or four-six weeks at -70°C.

Recombinant, E. coli

0.4 - 4 nM.

proNGF is the preferred ligand of p75^{NTR 1}. In contrast to its mature form proNGF induces apoptosis via p75^{NTR 1}, but can also mediate cell survival in DRGs² and in superior cervical ganglion (SCG)³.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Sterile water, DMEM at a concentration of at least 10 μg/ml. Centrifuge all product preparations before use (10000 x g 5 min). Repeated freezing/thawing might result in loss of activity.

Up to one week at 4°C or four-six weeks at -70°C.

Recombinant, E. coli

Persephin promotes the survival of mesencephalic, dopaminergic and motor neurons^1,2. The receptor for Persephin is a multicomponent complex composed of RET tyrosine kinase and the glycosyl-phosphatidylinositol (GPI)-anchored co-receptor GFR α1-α4^3,4.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Sterile water at a concentration of at least 1 µg/0.1 ml.
BSA (0.1 mg/ml) should be added for more diluted solutions. Centrifuge all product preparations before use (10000 x g 5 min). Repeated freezing/thawing might result in loss of activity.

Up to one week at 4°C or four-six weeks at -70°C.

Recombinant, E. coli

EC₅₀ = ~0.65-6.5 pM.

Pleiotrophin is a member of the heparin-binding neurotrophic factor family. It is a developmentally regulated neurotrophic factor which promotes neurite outgrowth, axonal guidance and synaptogenesis^1-4.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Sterile water at a concentration of at least 1 µg/0.1 ml.
BSA (0.1 mg/ml) should be added for more diluted solutions. Centrifuge all product preparations before use (10000 x g 5 min). Repeated freezing/thawing might result in loss of activity.

Up to one week at 4°C or four-six weeks at -70°C.