Overview
Alomone Labs is pleased to offer the NMDA Receptor Antibody Explorer Kit (#AK-214). This Explorer Kit includes antibodies targeted against NMDA receptors along with their respective peptide control antigen. An ideal tool for screening purposes.
Compounds
Scientific Background
The excitatory effects of glutamate (the major excitatory neurotransmitter) are mediated by the activation of ionotropic and metabotropic receptors. These receptors differ in their molecular, biochemical, physiological and pharmacological properties.
The ionotropic glutamate receptors are divided into three main categories: AMPA, NMDA (N-methyl-D-aspartate) and Kainate Receptors. NMDA receptors have a pivotal role in the regulation of synaptic function in the central nervous system. They are molecularly composed of three different subunits: NR1, NR2 and NR3 which can undergo alternative splicing.
