Overview
NMDA Receptor Interacting Protein Antibody Explorer Kit (#AK-615) contains specific antibodies directed against key proteins known to interact with NMDA Receptors.
Compounds
| Product Name | Cat # | Size |
|---|---|---|
Anti-AKAP150 Antibody |
APZ-031 | 1 x 50 µl |
AKAP150 Blocking Peptide |
BLP-PZ031 | 1 x 40 µg |
Anti-Homer1 Antibody |
APZ-026 | 1 x 50 µl |
Homer1 Blocking Peptide |
BLP-PZ026 | 1 x 40 µg |
Anti-Kidins220 Antibody |
APZ-017 | 1 x 50 µl |
Kidins220 Blocking Peptide |
BLP-PZ017 | 1 x 40 µg |
Anti-Pannexin 1 Antibody |
ACC-234 | 1 x 50 µl |
Pannexin 1 Blocking Peptide |
BLP-CC234 | 1 x 40 µg |
Anti-PICK1 Antibody |
APZ-014 | 1 x 50 µl |
PICK1 Blocking Peptide |
BLP-PZ014 | 1 x 40 µg |
Anti-PSD-93 Antibody |
APZ-002 | 1 x 50 µl |
PSD-93 Blocking Peptide |
BLP-PZ002 | 1 x 0.12 mg |
Anti-PSD-95 Antibody |
APZ-009 | 1 x 50 µl |
PSD-95 Blocking Peptide |
BLP-PZ009 | 1 x 40 µg |
Anti-SAP-97/DLG1 Antibody |
APZ-010 | 1 x 50 µl |
SAP-97/DLG1 Blocking Peptide |
BLP-PZ010 | 1 x 40 µg |
Anti-Shank1 Antibody |
APZ-011 | 1 x 50 µl |
Shank1 Blocking Peptide |
BLP-PZ011 | 1 x 40 µg |
Anti-Shank3 Antibody |
APZ-013 | 1 x 50 µl |
Shank3 Blocking Peptide |
BLP-PZ013 | 1 x 40 µg |
Anti-Sigma-1 Receptor Antibody |
AIP-006 | 1 x 50 µl |
Sigma-1 Receptor Blocking Peptide |
BLP-IP006 | 1 x 40 µg |
Scientific Background
NMDA receptors are encoded by seven genes: one NMDAR1 (or NR1) subunit, four NR2 (NR2A-NR2D) and two NR3 (NR3A-NR3B) subunits. The functional NMDA receptor appears to be a heterotetramer composed of two NMDAR1 and two NMDAR2 subunits. Whereas the NMDAR2 subunits that assemble with the NMDAR1 subunit can be either of the same kind (i.e. two NMDAR2A subunits) or different (one NMDAR2A with one NMDAR2B). NMDAR3 subunits can substitute the NMDAR2 subunits in their complex with the NMDAR1 subunit.
Ca2+ entry through the NMDAR regulates numerous downstream signaling pathways including long term potentiation (a molecular model of memory) and synaptic plasticity that may underlie learning. In addition, the NMDA receptors have been implicated in a variety of neurological disorders including epilepsy, ischemic brain damage, Parkinson’s and Alzheimer’s disease.
NMDA receptors expression and function are modulated by a variety of factors including receptor trafficking to the synapses and internalization as well as phosphorylation and interaction with other intracellular proteins.
- Dingledine, R. et al. (1999) Pharmacol. Rev. 51, 7.
- Mayer, M.L. and Armstrong, N. (2004) Annu. Rev. Physiol. 66, 161.
- Prybylowski, K. and Wenthold, R.J. (2004) J. Biol. Chem. 279, 9673.
- Mayer, M.L. (2006) Nature 440, 456.
