Name: NS19504
Brand: Alomone Labs
SKU: N-235
Rating: 4.65 (10 reviews)

Overview

Cat #: N-235

Lyophilized Powder yes

Source Synthetic

MW: 269.2

Purity: >99%

Effective concentration 5 µM – 100 µM.

Structure

Chemical name 5-[(4-bromophenyl)methyl]-1,3-thiazol-2-amine.

Molecular formula C₁₀H₉BrN₂S.

CAS No.: 327062-46-4

PubChem CID 727750

Activity NS19504 is a K_Ca1.1 channel opener¹.

References-Activity

Nausch, B. et al. (2014) J. Pharmacol. Exp. Ther. 350, 520.

Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Solubility 50 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Storage of solutions Up to four weeks at 4°C or three months at -20°C.

Our bioassay

Alomone Labs NS19504 enhances K_Ca1.1 channels expressed in Xenopus oocytes.
A. Time course of K_Ca1.1 channel activity at 55 mV demonstrating the effect of 10 and 50 μM NS19504 (#N-235). B. Representative current traces under control conditions and following application of 10 and 50 μM NS19504. Currents were elicited by a 100 ms voltage ramp from -80 to 80 mV every 10 seconds from a holding potential of -100 mV (current responses are shown between -40 and 80 mV).

References - Scientific background

Nausch, B. et al. (2014) J. Pharmacol. Exp. Ther. 350, 520.
Catacuzzeno, L. et al. (2015) Front. Cell. Neurosci. 9, 152.

Scientific background

NS19504 is a potent and selective activator of the large-conductance Ca²⁺-activated K⁺ channel, BK_Ca (K_Ca1.1). It activates heterologously expressed and native BK channels in a concentration-dependent manner with an EC₅₀ value of 11.0 ± 1.4 µM¹.

Several researches have indicated that NS19504 could reduce nonvoiding contractions associated with spontaneous bladder overactivity while having a minimal effect on voluntary bladder emptying.

BK_Ca channels are important regulators of urinary bladder function and may be used as an attractive therapeutic target in bladder disorders¹.

The large conductance Ca²⁺-activated K⁺ channels play a role in controlling the cell volume, they affect the driving force for Ca²⁺ influx and thus exert a secondary control on cell migration through regulation of Ca²⁺ signals by modulating the membrane potential².

Target K_Ca1.1 K⁺ channels

Lyophilized Powder

NS19504 (#N-235) is a highly pure, synthetic, and biologically active compound.

Certificate of Analysis SDS

For research purposes only, not for human use

Last Update: 07/05/2024

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NS19504

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