Overview
NS8593 hydrochloride (#N-195) is a highly pure, synthetic, and biologically active compound.
Structure
For research purposes only, not for human use
Applications
Citations (6)
Citations
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Properties
Technical Specifications
MW 299.79
Purity >99%
Molecular formula C17H18ClN3.
CAS No. 875755-24-1
Source Synthetic
Chemical name N-[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]-1H-benzimidazol-2-amine;hydrochloride.
Biological Activity
Target SK K+ channels, TRPM7
Effective concentration 100 nM -10 µM.
Activity NS8593 is KCa2 (SK) channel blocker, with no activity towards KCa3.1 channels, with IC50~100 nM1,2. It also blocks TRPM7 channels3.
References
- Jenkins, D.P. et al. (2011) Mol. Pharmacol. 79, 899.
- Strobaek, D. et al. (2006) Mol. Pharmacol. 70, 1771.
- Chubanov, V. et al. (2012) Br. J. Pharmacol. 166, 1357.
Solubility and Storage
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility 50 mM DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage of solutions Up to four weeks at 4°C or three months at -20°C.
Scientific Background
References
Scientific background
NS8593 inhibits the gating modulation of all SK, small conductance Ca2+-activated K+ channels (KCa2.1, KCa2.2, KCa2.3) and blocks SK3 channels with an IC50 of 104 nM1,2. It does so by shifting the apparent Ca2+-dependence to higher Ca2+ concentrations2. NS8593 has no effect on other KCa channels1.
NS8593 was also found to block TRPM7 currents with an IC50 value of 1.6 μM.
References
- Strobaek, D. et al. (2006) Mol. Pharmacol. 70, 1771.
- Jenkins, D.P. et al. (2011) Mol. Pharmacol. 79, 899.
- Chubanov, V. et al. (2012) Br. J. Pharmacol. 166, 1357.
Last Update: 08/01/2025
