Overview
Lyophilized Powder yes
Source Synthetic
MW: 299.79
Purity: >99%
Effective concentration 100 nM -10 µM.
Structure
Chemical name N-[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]-1H-benzimidazol-2-amine;hydrochloride.
Molecular formula C17H18ClN3.
CAS No.: 875755-24-1
Activity NS8593 is KCa2 (SK) channel blocker, with no activity towards KCa3.1 channels, with IC50~100 nM1,2. It also blocks TRPM7 channels3.
References-Activity
- Jenkins, D.P. et al. (2011) Mol. Pharmacol. 79, 899.
- Strobaek, D. et al. (2006) Mol. Pharmacol. 70, 1771.
- Chubanov, V. et al. (2012) Br. J. Pharmacol. 166, 1357.
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility 50 mM DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage of solutions Up to four weeks at 4°C or three months at -20°C.
Our bioassay
Alomone Labs NS8593 HCl blocks KCa2.2 (SK2) currents expressed in HEK 293T cells.A. Time course of KCa2.2 current amplitude and its blockade by 2 and 10 µM NS8593 hydrochloride (#N-195). Currents were elicited by application of voltage ramp from a holding potential of -100 mV to +60 mV (150 msec), delivered every 10 seconds. B: Superimposed example traces of current responses before and during perfusion of 2 and 10 µM NS8593 hydrochloride, as indicated.
Scientific background
NS8593 inhibits the gating modulation of all SK, small conductance Ca2+-activated K+ channels (KCa2.1, KCa2.2, KCa2.3) and blocks SK3 channels with an IC50 of 104 nM1,2. It does so by shifting the apparent Ca2+-dependence to higher Ca2+ concentrations2. NS8593 has no effect on other KCa channels1.
NS8593 was also found to block TRPM7 currents with an IC50 value of 1.6 μM.
Target SK K+ channels, TRPM7
Lyophilized Powder
For research purposes only, not for human use
Last Update: 07/05/2024
Specifications
Citations
Citations
