Overview
Lyophilized Powder yes
Origin Aspergillus ochraceus.
Source Natural
MW: 403.8
Purity: >98%
Effective concentration 100 nM - 1 μM.
Structure
Chemical name (-)-N-((5-Chloro-8-hydroxy-3-methyl-1-oxo-7-isochromanyl)carbonyl)-3-phenylalanine.
Molecular formula C20H18ClNO6.
CAS No.: 303-47-9
Activity Ochratoxin A causes an increase in ATP-driven Ca2+ pump activity in the ER1. Ochratoxin A also induces apoptosis in a JNK-dependent fashion2.
References-Activity
- Gekle, M. et al. (2000) J. Pharmacol. Exp. Ther. 293, 837.
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility Methanol. Centrifuge all product preparations before use (10000 x g 5 min).
Storage of solutions Up to one week at 4°C or three months at -20°C.
Protect from light.
Protect from light.
References - Scientific background
- Van der Merwe, K.J. et al. (1965) Nature 205, 1112.
- Creppy, E.E. (1999) J. Toxicol. Toxin Rev. 18, 277.
- Beardall, J.M. and Miller, J.D. (1994) In J. D. Miller and H. L. Trenholm (ed.), Eagan Press, St. Paul, Minn. 487.
- Chong, X. and Rahimtula, A.D. (1992) Biochem. Pharmacol. 44, 1401.
Scientific background Ochratoxin A is a natural metabolic alkaloid produce by Aspergillus ochraceus1. Ochratoxin A is a potent a toxin which causes nephrosis in mammals. In the circulation, Ochratoxin A has a very long half-life in all species examined2. Although the kidney is the primary target organ for Ochratoxin A activity, studies indicate that Ochratoxin A is also a liver toxin, immunosuppressant, potent teratogen, and carcinogen3. Ochratoxin A increases activity of the endoplasmic reticulum ATP-dependent Ca2+ pump4.
Target SERCA pump
Lyophilized Powder
Ochratoxin A (#O-400) is a highly pure, natural, and biologically active compound.
For research purposes only, not for human use
Last Update: 07/05/2024
Applications
Citations
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