Ochratoxin A

Specifications
Scientific Background

Overview

Cat #: AGC-036-AR

Purity: >98%

CAS No.: 303-47-9

MW: 403.8

Form: Lyophilized

Ochratoxin A (#O-400) is a highly pure, natural, and biologically active compound.

Certificate of Analysis SDS

Structure

For research purposes only, not for human use

Specifications

Properties

Technical Specifications

Origin Aspergillus ochraceus.

MW 403.8

Purity >98%

Molecular formula C₂₀H₁₈ClNO₆.

CAS No. 303-47-9

Source Natural

Chemical name (-)-N-((5-Chloro-8-hydroxy-3-methyl-1-oxo-7-isochromanyl)carbonyl)-3-phenylalanine.

Biological Activity

Target SERCA pump

Effective concentration 100 nM - 1 μM.

Activity Ochratoxin A causes an increase in ATP-driven Ca²⁺pump activity in the ER¹. Ochratoxin A also induces apoptosis in a JNK-dependent fashion².

References

Gekle, M. et al. (2000) J. Pharmacol. Exp. Ther. 293, 837.

Solubility and Storage

Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Solubility Methanol. Centrifuge all product preparations before use (10000 x g 5 min).

Storage of solutions Up to one week at 4°C or three months at -20°C.
Protect from light.

Scientific Background

References

Scientific background Ochratoxin A is a natural metabolic alkaloid produce by Aspergillus ochraceus¹. Ochratoxin A is a potent a toxin which causes nephrosis in mammals. In the circulation, Ochratoxin A has a very long half-life in all species examined². Although the kidney is the primary target organ for Ochratoxin A activity, studies indicate that Ochratoxin A is also a liver toxin, immunosuppressant, potent teratogen, and carcinogen³. Ochratoxin A increases activity of the endoplasmic reticulum ATP-dependent Ca²⁺ pump⁴.

References

Van der Merwe, K.J. et al. (1965) Nature 205, 1112.
Creppy, E.E. (1999) J. Toxicol. Toxin Rev. 18, 277.
Beardall, J.M. and Miller, J.D. (1994) In J. D. Miller and H. L. Trenholm (ed.), Eagan Press, St. Paul, Minn. 487.
Chong, X. and Rahimtula, A.D. (1992) Biochem. Pharmacol. 44, 1401.