Overview
Cat #:
STC-150
Alternative Name Omega-conotoxin MoVIA
Lyophilized Powder yes
Origin Conus moncuri (Sea snail)
Source Synthetic peptide
MW: 3607 Da
Purity: >98%
Form Lyophilized Powder
Effective concentration 100 nM – 2 µM
Sequence CKPXGSKCSXSMRDCCTTCISYTKRCRKYYN-OH
Modifications X = Hydroxyproline
Disulfide bonds location - Cys1-Cys16, Cys8-Cys19, Cys15-Cys26
Molecular formula C147H233N45O47S7
Activity A selective Cav2.2 blocker1
Accession number A0A384E129 Shipping and storage The product is shipped as a lyophilized powder at room temperature. Upon receipt, it should be stored at -20°C. Protect from moisture.
Solubility Soluble in water. For long-term storage in solution, we recommend to prepare a stock solution by dissolving the product in ddH2O at a concentration X100-1000 of final working solution. Divide the solution into small aliquots and store at -20°C. Upon use, thaw the relevant vial intended for use and dilute in your desired working buffer. The preparation of fresh solutions in working buffers before use is recommended. Repeat freeze-thawing might result in loss of activity. Centrifuge all product preparations before use (10000 x g, 5 min).
Storage of solutions The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the toxin in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.
Scientific background ω-Conotoxin MoVIA (MoVIA) is a 29 amino acid peptidyl toxin originally isolated from the venom of the western Pacific vermivorous (worm-hunting) cone snail, Conus moncuri. MoVIA is a specific and potent blocker of mammalian N-type voltage-gated Ca2+ channels (CaV2.2)1.
MoVIA has an arginine at position 13 instead of a tyrosine, which has been previously shown to be functionally critical for the potent Cav2.2 inhibitor activity of ω-conotoxins including ω-Conotoxin MVIIA (#C-670) and ω-Conotoxin GVIA (#C-300) from piscivorous (fish-hunting) species1.
CaV2.2 are predominantly expressed in nerve terminals and are involved in the regulation of neuronal excitability and nociceptive signaling. These channels are multifunctional and play important roles in the transduction of acute and chronic pain perception. They are able to transduce electrical activity into other cellular functions, regulate calcium homeostasis and process pain information. Since ω-conotoxins selectively inhibit Cav2.2 in nociceptors, they are considered attractive molecules for drug design2.
Target Cav2.2
Peptide Content: 100%
Lyophilized Powder
For research purposes only, not for human use
Last Update: 07/05/2024
