Overview
Lyophilized Powder yes
Source Synthetic
MW: 329.8
Purity: >99%.
Effective concentration 0.1-100 nM.
Structure
Chemical name 9-methyl-3-[(2-methylimidazol-1-yl)methyl]-2,3-dihydro-1H-carbazol-4-one;hydrochloride.
Molecular formula C18H20ClN3O.
CAS No.: 103639-04-9
Activity Ondansetron is a potent and selective 5-HT3A channel blocker with Ki ~ 10nM1.
References-Activity
- Youssefyeh, R.D. et al. (1992) J. Med. Chem. 35, 895.
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility 50 mg/ml in H2O. Centrifuge all product preparations before use (10000 x g 5 min).
Storage of solutions Up to four weeks at 4°C or three months at -20°C.
Our bioassay
Alomone Labs Ondansetron Hydrochloride blocks 5-HT3A receptors expressed in HEK 293T cells.Currents were elicited by 10 µM 5-HT, delivered every 3 minutes. Ondansetron hydrochloride (#O-110) was applied 30 seconds before stimulation at 2 and 20 nM, as indicated and inhibited the 5-HT induced current in a dose-dependent and reversible manner.
Target 5-Hydroxytryptamine Receptor 3A
Lyophilized Powder
For research purposes only, not for human use
Last Update: 30/03/2021
Specifications
Citations
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