Overview
Alternative Name Disipal®, Mebedrol®, Mephenamin®
Lyophilized Powder yes
Source Synthetic
MW: 305.8
Purity: >96%.
Effective concentration 0.3-100 µM.
Structure
Chemical name β-Dimethylaminoethyl 2-methylbenzhydryl ether hydrochloride.
Molecular formula C18H24ClNO.
CAS No.: 341-69-5
Activity Orphenadrine was found to act as muscarinic receptor antagonist, H1 histamine receptor antagonist, muscle relaxant, inhibitor of the noradrenergic transporter, NMDA receptor antagonist and NaV channel blocker1-4.
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage of solutions Up to four weeks at 4°C or three months at -20°C.
Our bioassay
Alomone Labs Orphenadrine hydrochloride inhibits charbacol-induced Ca2+ signaling in M1 muscarinic receptor expressing C6 cells.Changes in intracellular Ca2+ were detected via changes in Fluo-3 emission following application. A. Normalized fluorescence before and after co-application (at 20 seconds, see arrow) of 10 µM carbachol and 0-100 µM Orphenadrine hydrochloride (#O-101) as indicated. The blank response to PBS perfusion is in gray. B. Inhibition (as percent of control) of 10 µM Carbachol evoked Ca2+ rise, plotted against Orphenadrine concentrations.
Target Muscarinic, H1 histamine, NMDA receptors, NaV Na+ channels
Lyophilized Powder
For research purposes only, not for human use
Last Update: 30/03/2021
Specifications
Citations
Citations
