Overview
Alternative Name OXC, Trileptal®, Timox®
Lyophilized Powder yes
Source Synthetic
MW: 252.3
Purity: >98%.
Effective concentration 20 nM - 200 µM.
Structure
Chemical name 10,11-Dihydro-10-oxo-5H-dibenzo(Z)[b,f]azepine-5-carboxamide.
Molecular formula C15H12N2O2.
CAS No.: 28721-07-5
Activity Oxcarbazepine is an anticonvulsant drug. Its main mechanism of action is the inhibition of voltage-dependent Na+ channels1. Oxcarbazepine (IC50 = 50 nM) and its rapidly formed monohydroxy metabolite, MHD, (IC50 = 20 nM) inhibit sustained, high frequency, repetitive action potential firing of cultured spinal cord neurons2.
References-Activity
- Ambrosio, A. F. et al. (2002) Neurochem. Res. 27, 121.
- McLean, M. J. et al. (1994) Epilepsia 35, S55.
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage of solutions Up to one week at 4°C or three months at -20°C.
Our bioassay
Alomone Labs Oxcarbazepine inhibits NaV1.7 channels currents in HEK293 cells.A.Time course of current reversible inhibition by 200 μM Oxcarbazepine (#O-105). Currents were elicited by a voltage ramp from a holding potential of -100 mV to 60 mV (30 ms) delivered every 10 seconds. B. Example traces of current response to voltage ramp stimulation before and during 200 μM Oxcarbazepine application.
Target TTX-Sensitive NaV channels
Lyophilized Powder
For research purposes only, not for human use
Last Update: 30/03/2021
Specifications
Citations
Citations
