PD-160725 2-hydroxyethanesulfonate

Applications
Specifications
Scientific Background

Overview

Cat #: ANR-210-APC

Purity: >98%

CAS No.: 1262769-92-5

MW: 444.46

Form: Lyophilized

PD-160725 2-hydroxyethanesulfonate (#P-280) is a highly pure, synthetic, and biologically active compound.

Certificate of Analysis SDS

Alternative Name PD-160725 isethionate salt

Structure

For research purposes only, not for human use

Applications

Specifications

Properties

Technical Specifications

MW 444.46

Purity >98%

Molecular formula C₁₇H₂₄N₄O₈S.

CAS No. 1262769-92-5

Source Synthetic

PubChem CID 71312022

Chemical name 2-hydroxyethanesulfonic acid;6-methyl-7-nitro-5-(piperidin-1-ylmethyl)-1,4-dihydroquinoxaline-2,3-dione.

Biological Activity

Target AMPA receptors

Effective concentration 0.1-100 µM.

Activity PD-160725 2-hydroxyethanesulfonate is an AMPA receptor antagonist.

Solubility and Storage

Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Solubility Up to 20 mM in H₂O (slowly, clear yellow solution). Centrifuge all products before reconstitution (10000 x g 5 min).

Storage of solutions Up to four weeks at 4°C or three months at -20°C. It is recommended to aliquot reconstituted stock solutions.

Scientific Background

References

Scientific background

PD-160725 2-hydroxyethanesulfonate is an AMPA receptor antagonist. Antagonists of AMPA receptors are good candidates for potential treatment of several neurological disorders including epilepsy, stroke and amyotrophic lateral sclerosis^1,2.

The ionotropic glutamate AMPA receptors (AMPARs) are the primary receptors that mediate fast excitatory synaptic transmission in the mammalian brain. The majority of this transmission in the mammalian central nervous system is mediated by the release of glutamate from the presynaptic terminal and its binding to glutamate receptors on the postsynaptic membrane².