Overview
PD 98059 (#P-260) is a highly pure, synthetic, and biologically active compound.
Structure
For research purposes only, not for human use
Applications
Citations (2)
Citations
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Properties
Technical Specifications
MW 267.28
Purity >99%
Molecular formula C16H13NO3.
CAS No. 167869-21-8
Source Synthetic
Chemical name 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one.
Biological Activity
Effective concentration 1-80 µM.
Activity PD 98059 specifically inhibits the mitogen-activated protein kinase kinase (MAPKK) also known as MEK1 and MEK2. It is commonly used in studies of the MAPK pathway.
References
- Dudley, D.T. et al. (1995) Proc. Natl. Acad. Sci. U.S.A. 92, 7686.
Solubility and Storage
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage of solutions Up to two weeks at 4°C or six months at -20°C.
Protect from light.
Protect from light.
Scientific Background
References
Scientific background
PD 98059 is a synthetic flavonoid and a potent inhibitor of mitogen-activated protein kinase (MAPK) by inhibiting its immediate upstream activator, mitogen activated protein kinase kinase (also known as MEK or MKK1).1-3
PD 98059 arrests cell cycle progression of some rat cultured cells at the G0/G1 phase and blocks nerve growth factor stimulated axonal outgrowth from adult mouse dorsal root ganglia in vitro,4-5 and blocks induction of LTP in the brain areas.6-7
PD 98059 is also an equipotent antagonist of aryl hydrocarbon receptor (AHR) stimulated by TCDD in MCF10A cells. 8-10
References
- Alessi, D.R. et al. (1995) J. Biol. Chem. 270, 27489.
- Dudley, D.T. et al. (1995) Proc. Natl. Acad. Sci. 92, 7686.
- Pang, L. et al. (1995) J. Biol. Chem. 270, 13585.
- Yamaguchi, K. et al. (2002) J. Ophthalmol. 46, 634.
- Sjogreen, B. et al. (2000) Neuroscience 100, 407.
- Coogan, A.N. et al. (1999) J. Neurophysiol. 81, 103.
- English, J. D. et al. (1997) J. Biol. Chem. 272, 19103.
- Guyton, K.Z. et al. (1996) Cancer Res. 56, 3480.
- Cook, S.J. et al. (1997) J. Biol. Chem. 272, 13309.
- Reiners, J.J. Jr. et al. (1998) Mol. Pharmacol. 53, 438.
Last Update: 08/01/2025
