Overview
Penitrem A (#P-650) is a highly pure, natural, and biologically active compound.
Alternative Name Tremortin A
Structure
For research purposes only, not for human use
Applications
Citations (9)
Citations
Powered by BiozProduct citations
- Ishii, H. et al. (2010) Eur. J. Neurosci. 32, 736.
- Rancz, E.A. and Häusser, M. (2010) Proc. Natl. Acad. Sci. U.S.A. 107, 22284.
- Donato, R. et al. (2006) J. Neurosci. 26, 12576.
- Rancz, E.A. and Häusser, M. (2006) J. Neurosci. 26, 5428.
Specifications
Properties
Technical Specifications
Origin Penicillium palitans.
MW 634.2
Purity >98%
Molecular formula C37H44ClNO6.
CAS No. 12627-35-9
Source Natural
Biological Activity
Target KCa1.1 K+ channels
Effective concentration 10-100 nM.
Activity Penitrem A is a selective blocker of KCa1.1 (high-conductance Ca2+-activated K+, BK) channels1. Penitrem A increases the spontaneous release of endogenous GABA (3-aminobutyric acid), and aspartate2.
References
- Hollywood, M. A. et al. (2000) Am. J. Physiol. 279, C420.
- Norris, P.J. et al. (1980) J. Neurochem. 34, 33.
Solubility and Storage
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility DMSO, methanol, acetone. Centrifuge all product preparations before use (10000 x g 5 min).
Storage of solutions Up to one week at 4°C or three months at -20°C.
Scientific Background
References
Scientific background Penitrem A is widely used to probe KCa1.1 channels in smooth muscle preparations, where it induces prolongation of the depolarization plateau potential.1 Penitrem A is a selective blocker of KCa1.1 (high-conductance Ca2+-activated K+, BK) channels. It belongs to a set of tremorgenic indole alkaloids which are lipid soluble and also include Verruculogen (#V-500) and Paxilline (#P-450).2 Penitrem A (400 mg mycelium/kg) increased the spontaneous release of endogenous glutamate, GABA (γ-aminobutyric acid), and aspartate by 213%, 455%, and 277%, respectively, from rat cerebrocortical synaptosomes.3
References
- Hollywood, M. A. et al. (2000) Am. J. Physiol. 279, C420.
- Knaus, H. G. et al. (1994) Biochemistry 33, 5819.
- Norris, P.J. et al. (1980) J. Neurochem. 34, 33.
Last Update: 08/01/2025
