Overview
Alternative Name Tremortin A
Lyophilized Powder yes
Origin Penicillium palitans.
Source Natural
MW: 634.2
Purity: >98%
Effective concentration 10-100 nM.
Structure
Molecular formula C37H44ClNO6.
CAS No.: 12627-35-9
Activity Penitrem A is a selective blocker of KCa1.1 (high-conductance Ca2+-activated K+, BK) channels1. Penitrem A increases the spontaneous release of endogenous GABA (3-aminobutyric acid), and aspartate2.
References-Activity
- Hollywood, M. A. et al. (2000) Am. J. Physiol. 279, C420.
- Norris, P.J. et al. (1980) J. Neurochem. 34, 33.
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility DMSO, methanol, acetone. Centrifuge all product preparations before use (10000 x g 5 min).
Storage of solutions Up to one week at 4°C or three months at -20°C.
Our bioassay
Alomone Labs Penitrem A inhibits KCa1.1 (BK) channels heterologously expressed in Xenopus oocytes.The effect of 100 nM Paxilline (#P-450) (a), Penitrem A (#P-650) (b) and Verruculogen (#V-500) (c) on BK currents. Time course of current amplitude changes upon sequential application of the three toxins.
Scientific background Penitrem A is widely used to probe KCa1.1 channels in smooth muscle preparations, where it induces prolongation of the depolarization plateau potential.1 Penitrem A is a selective blocker of KCa1.1 (high-conductance Ca2+-activated K+, BK) channels. It belongs to a set of tremorgenic indole alkaloids which are lipid soluble and also include Verruculogen (#V-500) and Paxilline (#P-450).2 Penitrem A (400 mg mycelium/kg) increased the spontaneous release of endogenous glutamate, GABA (γ-aminobutyric acid), and aspartate by 213%, 455%, and 277%, respectively, from rat cerebrocortical synaptosomes.3
Target KCa1.1 K+ channels
Lyophilized Powder
For research purposes only, not for human use
Last Update: 02/01/2024
Specifications
Citations
Citations
