Overview
Lyophilized Powder yes
Source Synthetic
MW: 592.7
Purity: >99%.
Effective concentration 100 nM - 5 µM.
Structure
Chemical name 1,5-Bis(p-amidinophenoxy)pentane bis(2-hydroxyethanesulfonate salt).
Molecular formula C23H36N4O10S2.
CAS No.: 140-64-7
PubChem CID 8813
Activity Pentamidine is an uncompetitive NMDA receptor antagonist. It is neuroprotective and inhibits constitutive nitric oxide synthase in the brain. IC50 = 0.72 μM (NR2A), 1.5 μM (NR2B), 10 μM (NR2C), 9.1 μM (NR2D)1.
References-Activity
- Reynolds, I.J. and Aizenman, E. (1992) J. Neurosci. 12, 970.
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility 50 mM in H2O. Centrifuge all product preparations before use (10000 x g 5 min).
Storage of solutions Up to four weeks at 4°C or three months at -20°C.
Our bioassay
Alomone Labs Pentamidine isethionate salt inhibits NMDA (NR1+NR2A) channels expressed in Xenopus oocytes.A. Time course of NMDA currents that were elicited by stimulation with 10 µM glutamate co-applied with 10 µM glycine every 50 sec, while membrane potential was held at -80 mV. 1 and 10 µM Pentamidine isethionate salt (#P-155), applied for 4 min each, as indicated, reversibly inhibited current amplitude. B. Superimposed current traces taken from the experiment described in A.
Target NMDA receptors
Lyophilized Powder
For research purposes only, not for human use
Last Update: 30/03/2021
Specifications
Citations
Citations
