Overview
Alternative Name Sernylan, Elysion, PCP hydrochloride, Sernyl hydrochloride
Lyophilized Powder yes
Source Synthetic
MW: 279.85
Purity: >97%.
Effective concentration 0.1 µM – 1 µM.
Structure
Chemical name 1-(1-Phenylcyclohexyl) piperidine hydrochloride.
Molecular formula C17H26ClN.
CAS No.: 956-90-1
PubChem CID 9795678
Activity Phencyclidine is a non-competitive antagonist of NMDA glutamate receptors (IC50 = 0.821 µM on NR1/2A in oocytes at pH 7.6)1.
References-Activity
- Dravid, S.M. et al. (2007) J. Physiol. 581, 107.
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility 50 mM in H2O. Centrifuge all product preparations before use (10000 x g 5 min).
Storage of solutions Up to four weeks at 4°C or three months at -20°C.
Our bioassay
Alomone Labs Phencyclidine hydrochloride inhibits NMDA receptor channels (NR1+NR2A) expressed in Xenopus oocytes.A. Time course of NMDAR currents, elicited by transient stimulations with 100 µM glutamate and 100 µM glycine every 100s, while membrane potential was held at -80 mV. 0.5 µM Phencyclidine hydrochloride (#P-125), applied for 8 min (bar), significantly inhibited current amplitude. B. Superimposed current traces from the recording shown in A, upon application of control and of 0.5 µM Phencyclidine hydrochloride (as indicated).
Target NMDA receptors
Lyophilized Powder
For research purposes only, not for human use
Last Update: 30/03/2021
Specifications
Citations
Citations
