Overview
Alternative Name Dilantin, Diphenylhydantoin, Phenytoine, Aleviatin
Lyophilized Powder yes
Source Synthetic
MW: 252.09
Purity: ≥98%.
Effective concentration 10 -500 μM.
Structure
Chemical name 5,5-diphenylimidazolidine-2,4-dione.
Molecular formula C15H12N2O2.
CAS No.: 57-41-0
PubChem CID 1775
Activity Phenytoin blocks NaV channels with an IC50 ~50 µM on rat cerebrocortical neurons1.
References-Activity
- Ragsdale, D.S. et al. (1991) Mol. Pharmacol. 40, 756.
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility 200 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage of solutions Up to four weeks at 4°C or three months at -20°C.
Our bioassay
Alomone Labs Phenytoin inhibits NaV1.2 channel currents in Xenopus oocytes.A. Time course of current reversible inhibition by 50 and 250 µM Phenytoin (#P-235), as measured at peak current amplitude. Currents were elicited by a voltage step protocol from a holding potential of -60 mV to -10 mV delivered every 10 seconds. B. Example traces of current responses before and during 50 and 250 µM Phenytoin application.
Scientific background
Phenytoin is an anticonvulsant drug used in the treatment of grand mal and psychomotor epilepsy and protects against convulsions that occur during or after neurosurgery or due to severe head trauma. It is also administered for the treatment of trigeminal neuralgia, and certain psychoses and can be applied in the treatment of cardiac arrhythmia, digital intoxication, and myocardial infarction. In dermatology this drug is being used to treating ulcers and epidermolysis bullosa1,2.
Phenytoin has also been shown to block neuronal NaV channels3.
Target NaV channels
Lyophilized Powder
For research purposes only, not for human use
Last Update: 30/03/2021
Specifications
Citations
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