Overview
Alternative Name ω-Plectoxin-Pt1a, ω-PLTX-Pt1a, PLTX-2
Lyophilized Powder yes
Origin Natural peptide isolated from Plectreurys tristis (Spider).
MW: 5109 Da
Purity: >99% (HPLC)
Effective concentration 10-50 nM.
Sequence ADCSATGDTCDHTKKCCDDCYTCRCGTPWGANCRCDYYKARCDT.
Modifications Disulfide bonds between Cys3-Cys17, Cys10-Cys23, Cys16-Cys35, Cys20-Cys42 and Cys25-Cys33. Thr44 - C-terminal amidation and Opalmitoylation.
Structure
Molecular formula C208H312N60O71S10.
Activity PLTX-II is a voltage-gated Ca2+ channel blocker.
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility Water or 0.9% NaCl solution. Centrifuge all product preparations before use (10000 x g 5 min).
Storage of solutions Up to one week at 4°C or three months at -20°C.
References - Scientific background
- Leung, H.T. et al. (1989) Neuron 3, 767.
- Branton, W.D. et al. (1993) Nature 365, 496.
- Gu, H. et al. (2009) J. Neurophysiol. 101, 42.
- Hou, J. et al. (2008) J. Neurophysiol. 100, 2833.
Scientific background Plectreurys toxin (PLTX-II) is a 44 amino acid peptidyl toxin produced by Plectreurys tristis spider1,2. PLTXII was found as a potent blocker of the CaV2 channel (CAC) that inactivates Ca2+ currents in pupal neurons3 and in antennal lobe PNs of adult Drosophila brain. PLTX-II regulates the miniature excitatory postsynaptic current frequency at excitatory cholinergic synapses of these neurons in vitro and in situ and acts as a presynaptic Ca2+-channel blocker3,4.
Target CaV Ca2+ channels
Peptide Content: 100%
Lyophilized Powder
PLTX-II (#P-510) is a highly pure, natural, and biologically active peptide toxin.
For research purposes only, not for human use
Last Update: 02/01/2024
Applications
Citations
Citations
Powered by BiozProduct citations
- Ormerod, K.G. et al. (2013) J. Neurophysiol. 110, 1984.
- Chen, Z. et al. (2010) J. Neurosci. 30, 6247.
- Hartwig, C.L. et al. (2008) Dev. Neurobiol. 68, 1225.
- Worrell, J.W. and Levine, R.B. (2008) J. Neurophysiol. 100, 868.
