Membrane Proteins in Inflammation Antibody Explorer Kit

Inflammation is a non-specific immune response of the body that occurs in reaction to any type of bodily injury. During this response, leukocytes and plasma proteins are recruited from blood into the tissues and activate an immune response. Inflammation is triggered by recognition of pathogen and damage associated molecular patterns from injured tissues during innate immune responses which is prolonged during adaptive immune responses^1,2.

The reactions of the immune system involve cytokines which are produced by dendritic cells, macrophages, and other types of cells during innate immune reactions. The leukocytes that are mostly recruited in inflammation are neutrophils, and monocytes¹.

Infections usually exist in peripheral tissue inflammation which may cause an increase in blood flow into lymph nodes and consequently an increase in T lymphocyte influx into lymph nodes at the site of inflammation. In addition to increased blood flow, signs of inflammation include elevated cellular metabolism, vasodilatation, release of soluble mediators, extravasation of fluids and cellular influx^1,2.