Overview
Alternative Name Pyrrolopyrimidine 14, BDBM14191, N-{7-cyclohexyl-7H-pyrrolo[2,3-d]pyrimidin-2-yl}-4-(2-methoxyethyl)piperazin-1-amine
Lyophilized Powder yes
Source Synthetic
MW: 385.46
Purity: >99% (HPLC)
Effective concentration 50 nM - 20 µM.
Structure
Chemical name 7-benzyl-4-(1-pyridin-2-ylpiperidin-4-yl)oxypyrrolo[2,3-d]pyrimidine.
Molecular formula C23H23N5O.
PubChem CID 73755149
Activity Pyrrolopyrimidine 48 is a blocker of NaV1.7 channel with an IC50 value of 0.11 µM. It also blocks NaV1.5 channel with an IC50 of 0.16 µM1.
References-Activity
- Chakka, N. et al. (2012) Bioorg. Med. Chem. Lett. 22, 2052.
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility 50 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage of solutions Up to four weeks at 4°C or three months at -20°C.
Our bioassay
Alomone Labs Pyrrolopyrimidine 48 blocks NaV1.7 channels expressed in Xenopus oocytes.A. Time course of NaV1.7 current amplitude and inhibition by 1 and 10 µM Pyrrolopyrimidine 48 (#P-275). Currents were elicited by application of a 20 ms voltage step to 0 mV (H.P= -100 mV), every 10 seconds. B. Superimposed example traces of current responses before and during perfusion of 1 and 10 µM Pyrrolopyrimidine 48, as indicated.
Scientific background
Pyrrolopyrimidine 48 is a blocker of NaV1.7 channel developed using structure-activity relationship of the channel. It blocks human NaV1.7 with an IC50 value of 0.11 µM and NaV1.5 channel with an IC50 of 0.16 µM. It exhibits good selectivity over hERG K+ channel1.
Target NaV1.7, NaV1.5 channels
Lyophilized Powder
For research purposes only, not for human use
Last Update: 07/05/2024
Specifications
Citations
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