Overview
QX-314 bromide (#Q-100) is a highly pure, synthetic, and biologically active compound.
Alternative Name Lidocaine N-ethyl bromide
Structure
For research purposes only, not for human use
Applications
Citations (57)
Citations
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Specifications
Properties
Technical Specifications
MW 343.3
Purity >99% (HPLC)
Molecular formula C16H27N2OBr.
CAS No. 21306-56-9
Source Synthetic
Chemical name N-(2,6-Dimethylphenylcarbamoylmethyl) triethylammonium bromide.
Biological Activity
Target Various NaV Na+ channels
Effective concentration 1-50 mM.
Activity QX-314 bromide is an intracellular blocker of NaV channels1-4.
References
- Llinas, R. and Yarom, Y. (1981) J. Physiol. 315, 549.
- Congar, P. et al. (1995) J. Neurophysiol. 73, 421.
- Li, D.P. et al. (2005) J. Neurophysiol. 93, 393.
- Koike-Tani, M. (2005) J. Neurosci. 25, 199.
Solubility and Storage
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for four years.
Solubility Water. Centrifuge all product preparations before use (10000 x g 5 min).
Storage of solutions Up to two weeks at 4°C or six months at -20°C.
Protect from light. Hygroscopic.
Protect from light. Hygroscopic.
Scientific Background
References
Scientific background This local anesthetic is a blocker of voltage-dependent Na+ channels. QX-314 blocks all NaV channels once exposed to the intracellular face of the channel protein. However, this compound can penetrate the cell interior once applied outside the cell. Via certain types of NaV channels, it can permeate and exert blocking activity via TTX-sensitive channels.1 Intracellular recordings from inferior olivary neurons in brain stem slice preparations demonstrated that the Na+-dependent action potential was completely blocked for approximately five minutes after impalement with a microelectrode containing 50 mM QX-314, whereas the low-threshold Ca2+ spike was still generated.2 QX-314 is widely used to block NaV channels and used as a tool in neurophysiological recordings.2-5
References
- Sunami, A. et al. (2000) Proc. Natl. Acad. Sci. U.S.A. 97, 2326.
- Llinas, R. and Yarom, Y. (1981) J. Physiol. 315, 549.
- Congar, P. et al. (1995) J. Neurophysiol. 73, 421.
- Li, D.P. et al. (2005) J. Neurophysiol. 93, 393.
- Koike-Tani, M. (2005) J. Neurosci. 25, 199.
Last Update: 12/03/2025
