Overview
Alternative Name Nasea, YM 060
Lyophilized Powder yes
Source Synthetic
MW: 315.8
Purity: ≥99.5%.
Effective concentration 0.1 nM – 0.1 µM.
Structure
Chemical name (1-methylindol-3-yl)-[(5R)-4,5,6,7-tetrahydro-3H-benzimidazol-5-yl]methanone;hydrochloride.
Molecular formula C17H18ClN3O.
CAS No.: 132907-72-3
PubChem CID 107999
Activity Ramosetron is a 5-HT3 receptor antagonist1.
References-Activity
- Ito, H. et al. (1992) J. Pharmacol. Exp. Ther. 263, 1127.
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility 100 mM in H2O. Centrifuge all product preparations before use (10000 x g 5 min).
Storage of solutions Up to four weeks at 4°C or three months at -20°C.
Our bioassay
Alomone Labs Ramosetron hydrochloride blocks 5-HT3A receptors expressed in HEK 293T cells.5-HT3A receptor currents were elicited by 10µM 5-HT, delivered every 3 minutes. Ramosetron hydrochloride (#R-145) was applied 30 seconds before stimulation at 0.5, 1 and 20 nM as indicated and completely inhibited the 5-HT induced current in a dose dependent manner.
Target 5-HT3 receptors
Lyophilized Powder
For research purposes only, not for human use
Last Update: 30/03/2021
Specifications
Citations
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