Overview
Alternative Name RAPA, Rapamune, Sirolimus, AY-22989, NSC-226080
Lyophilized Powder yes
Origin Streptomyces hygroscopicus subsp. hygroscopicus.
Source Natural
MW: 914.2
Purity: >99%.
Effective concentration 1-20 nM.
Structure
Chemical name (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34 aS)9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hex adecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4- hydro xy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy- 6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido[2,1-c] [1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)- pentone.
Molecular formula C51H79NO13.
CAS No.: 53123-88-9
Activity Rapamycin is an antifungal antibiotic with immunosuppressive activities1. It can inhibit calcineurin when in complex with FKBP122. Rapamycin also exhibits anticancer properties3.
References-Activity
- Cardenas, M. et al. (1994) Perspect. Drug Discov. Des. 2, 103.
- Fruman, D.A. et al. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 3686.
- Edinger, A.L. et al. (2003) Cancer Res. 63, 8451.
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility DMSO, methanol. Centrifuge all product preparations before use (10000 x g 5 min).
Storage of solutions Up to two weeks at 4°C or three months at -20°C.
Our bioassay
Alomone Labs Rapamycin inhibits the proliferation of WEHI B lymphocyte cells.Cells were treated with different concentrations of Rapamycin (#R-900) for 4 days; the number of live cells was measured by XTT cell proliferation assay kit, normalized to the control (100%) and plotted against the drug concentration.
Lyophilized Powder
For research purposes only, not for human use
Last Update: 30/03/2021
Specifications
Citations
Citations
