Overview
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Cat #:
A-266
Purity: >95%
CAS No.: 171259-81-7
MW: 267.07
Form: Lyophilized
(RS)-AMPA hydrobromide (#A-266) is a highly pure, synthetic, and biologically active compound.
Alternative Name AMPA, (+/-)-AMPA hydrobromide
MW: 267.07
Structure
For research purposes only, not for human use
Applications
Our Bioassay
Our bioassay
- Alomone Labs (RS)-AMPA hydrobromide activates GluA1 channels expressed in Xenopus oocytes.Time course of current reversible activation by 0.1, 1 and 10 μM (RS)-AMPA hydrobromide (#A-266) followed by glutamate elicited currents (0.1, 1 and 10 μM, holding potential -80 mV) for comparison.
Citations (21)
Citations
Specifications
Properties
Technical specifications
MW 267.07
Purity >95%
Molecular formula C7H11BrN2O4.
CAS No. 171259-81-7
Source Synthetic
PubChem CID 11957558
Chemical name 2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-yl)propanoic acid;hydrobromide.
Biological activity
Target AMPA receptors
Effective concentration 0.1-100 µM.
Activity (RS)-AMPA is a selective AMPA receptor agonist1.
References
- Traynelis, S.F. et al. (2010) Pharmacol. Rev. 62, 405.
Solubility and storage
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility 50 mM in H2O. Centrifuge all product preparations before use (10,000 x g for 1 min).
Storage of solutions Up to four weeks at 4°C or three months at -20°C.
Scientific Background
References
Scientific background
Glutamate is the main excitatory neurotransmitter in the CNS. It is also involved in a variety of pathological conditions including epilepsy. Glutamate binds to a number of different receptor types such as the AMPA, kainate and NMDA receptors that relay its excitatory activity.
(RS)-AMPA is a synthetic AMPA receptor agonist. It has an effective concentration of 0.1-100 µM. RS-AMPA selectively binds to AMPA receptors over the other types of glutamate receptors. RS-AMPA was found to elicit feeding behavior in a rat model while RS-AMPA’s enantiomer did not produce similar results1.
References
- Howes, J.F. and Bell, C. (2007) Neurotherapeutics 4, 126.
Last Update: 07/05/2024