Overview
Alternative Name AMPA, (+/-)-AMPA hydrobromide
Lyophilized Powder yes
Source Synthetic
MW: 267.07
Purity: >95%
Effective concentration 0.1-100 µM.
Structure
Chemical name 2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-yl)propanoic acid;hydrobromide.
Molecular formula C7H11BrN2O4.
CAS No.: 171259-81-7
PubChem CID 11957558
Activity (RS)-AMPA is a selective AMPA receptor agonist1.
References-Activity
- Traynelis, S.F. et al. (2010) Pharmacol. Rev. 62, 405.
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility 50 mM in H2O. Centrifuge all product preparations before use (10,000 x g for 1 min).
Storage of solutions Up to four weeks at 4°C or three months at -20°C.
Our bioassay
Alomone Labs (RS)-AMPA hydrobromide activates GluA1 channels expressed in Xenopus oocytes.Time course of current reversible activation by 0.1, 1 and 10 μM (RS)-AMPA hydrobromide (#A-266) followed by glutamate elicited currents (0.1, 1 and 10 μM, holding potential -80 mV) for comparison.
References - Scientific background
- Howes, J.F. and Bell, C. (2007) Neurotherapeutics 4, 126.
Scientific background
Glutamate is the main excitatory neurotransmitter in the CNS. It is also involved in a variety of pathological conditions including epilepsy. Glutamate binds to a number of different receptor types such as the AMPA, kainate and NMDA receptors that relay its excitatory activity.
(RS)-AMPA is a synthetic AMPA receptor agonist. It has an effective concentration of 0.1-100 µM. RS-AMPA selectively binds to AMPA receptors over the other types of glutamate receptors. RS-AMPA was found to elicit feeding behavior in a rat model while RS-AMPA’s enantiomer did not produce similar results1.
Target AMPA receptors
Lyophilized Powder
(RS)-AMPA hydrobromide (#A-266) is a highly pure, synthetic, and biologically active compound.
For research purposes only, not for human use
Last Update: 07/05/2024
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