Overview
Lyophilized Powder yes
Source Synthetic
MW: 337.2
Purity: >99%
Effective concentration 100 nM - 10 µM.
Structure
Chemical name 2-(diethylamino)ethyl 4-amino-5-chloro-2-methoxybenzoate;hydrochloride.
Molecular formula C14H22Cl2N2O3.
CAS No.: 137196-67-9
Activity SDZ 205-557 hydrochloride is a 5-HT3 and 5-HT4 receptor antagonist1.
References-Activity
- Eglen, R.M. et al. (1993) Br. J. Pharmacol. 108, 376.
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility 65 mg/ml in H2O. 100mg/ml in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage of solutions Up to four weeks at 4°C or three months at -20°C.
Our bioassay
Alomone Labs SDZ 205-557 hydrochloride blocks 5-HT3A receptors expressed in HEK 293T cells.Currents were elicited by 10 µM 5-HT, delivered every 3 minutes. SDZ 205-557 hydrochloride (#S-145) was applied 30 seconds before stimulation at 1 and 10 µM, as indicated and inhibited the 5-HT induced current in a dose-dependent and reversible manner.
Scientific background
SDZ 205-557 is a potent 5-HT3 and 5-HT4 receptor antagonist with a greater affinity for 5-HT4 receptor with a Ki value of 10.6 nM3. It lacks affinity for other 5-HT receptors. SDZ 205-557 is thus suggested to be used as a useful ligand to characterize and define the 5HT-4 receptor. SDZ 205-557 has the ability to cross the blood brain barrier and has a short duration of action that may complicate its use in vivo1,3.
5-HT3 and 5HT4 are members of the serotonin-gated and G protein coupled receptor superfamily respectively. 5-HT3 receptors are expressed throughout the central and peripheral nervous systems. High levels of 5-HT4 receptors can be found in the olfactory system, striatum, hippocampus, and substantia nigra2,3.
Target 5-HT3, 5HT4 receptors
Lyophilized Powder
For research purposes only, not for human use
Last Update: 07/05/2024
Specifications
Citations
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