Overview
Alomone Labs is pleased to offer the SERCA Pump Inhibitor Explorer Kit (#EK-365). The Explorer Kit contains SERCA pump inhibitors, ideal for screening purposes.
Compounds
| Product Name | Cat # | Size |
|---|---|---|
Chelerythrine chloride |
C-400 | 1 x 1 mg |
Cyclopiazonic Acid |
C-750 | 1 x 5 mg |
NS-1619 |
N-105 | 1 x 5 mg |
Ochratoxin A |
O-400 | 1 x 0.5 mg |
Paxilline |
P-450 | 1 x 0.45 mg |
Thapsigargin |
T-650 | 1 x 0.65 mg |
Scientific Background
SERCA pumps are located in both the endoplasmic reticulum and in the Golgi membranes. They are known to transport two Ca2+ molecules per hydrolysis of one ATP1. Their structure includes ten transmembrane domains and their main role is to remove cytoplasmic Ca2+ ions in order to promote muscle relaxation1.
In mammals three genes encode three SERCA pumps. Each transcript undergoes tissue-dependent alternative splicing. SERCA1a and 1b are expressed in adult and neonatal skeletal muscle respectively. SERCA2a is also expressed in skeletal muscle, while SERCA2b is ubiquitously expressed. SERCA3 is expressed in a limited number of non-muscle cells2. Although all SERCAs are regulated, SERCA2b undergoes extensive regulation at the protein level, such as protein-protein interaction, phosphorylation and glycosylation1.
- Vandecaetsbeek, I. et al. (2011) Cold Spring Harb. Perspect. Biol. 3, a004184.
- Brini, M. et al. (2009) Physiol. Rev. 89, 1341.
