Chemical name 3-(2-aminoethyl)-1H-indol-5-ol;hydrochloride.
Molecular formula C10H13ClN2O.
CAS No.: 153-98-0
PubChem CID 160436
Activity Serotonin is an endogenous agonist at 5-HT receptors and endogenous substrate for 5-HT transporters. Neurotransmitter that has roles in regulation of mood, emesis, sexuality, sleep and appetite in vivo1.
References-Activity
Barnes, N.M. et al. (1999) Neuropharmacology38, 1083.
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility 150 mM in water. Centrifuge all product preparations before use (10000 x g 5 min).
Storage of solutions Up to four weeks at 4°C or three months at -20°C.
5-HT3A receptor currents were elicited by 1 or 10 µM Serotonin hydrochloride (#S-165), as indicated. 0.1 µM failed to activate currents here.
Scientific background
Serotonin is the endogenous agonist of 5-HT receptors and the endogenous substrate for the synthesis of a number of molecules, such as melatonin, formyl5hydroxykynurenamine, and 5hydroxyindoleacetic acid.
Serotonin (5HT), also known as 5hydroxytryptamine is a monoamine derived from tryptophan. Primarily, serotonin can be found in the gastrointestinal tract, blood platelets, and the central nervous system (CNS)1. Only 2% of serotonin is present in the CNS where it plays an important role in the etiology of many mental disorders. 5-HT also plays an important role in regulating mood and social behavior, appetite, sleep, pain, bone density, tissue regeneration, platelet aggregation, gastrointestinal function, memory and sexual desire and function1,2. In addition, serotonin affects the immune, gastrointestinal and nervous systems in a paracrine, endocrine, and juxtacrine manner2.
An extensive use or overdose of serotonergic drugs can lead to a rare life threatening syndrome called serotonin syndrome that includes mental status changes, neuromuscular abnormalities and autonomic hyperactivity3.