Recombinant, E. coli

100 nM - 1 µM.

Aa1 Toxin is a blocker of A-type voltage-gated transient K⁺ channels of cerebellar granular cells^1,2.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to one week at 4°C or three months at -20°C.

Synthetic peptide

1 pM - 2 nM.

Selective potent K_V1.3 blocker^1-3.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any other aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to two weeks at 4°C or three months at -20°C.

Synthetic peptide

<1 nM.

Agitoxin-1 is a blocker of Shaker voltage-gated K⁺ channels as well as the mammalian homologues of Shaker.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to one week at 4°C or three months at -20°C.

Synthetic peptide

50 pM - 10 nM.

Agitoxin-2 is a blocker of Shaker voltage-gated K⁺ channels as well as the mammalian homologues of Shaker.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any other aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to two week at 4°C or three months at -20°C.

Synthetic peptide

10-100 nM.

Charybdotoxin is a potent selective inhibitor of high conductance (maxi-K), different medium and small conductance Ca²⁺-activated K⁺ channels, as well as a voltage-dependent K⁺ channel (K_V1.3)¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to two weeks at 4°C or three months at -20°C.

Synthetic peptide

30 nM.

κ-Conotoxin RIIIJ is a blocker of K_V1.2 channels¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any other aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to two weeks at 4°C or three months at -20°C.

1-200 µM.

CP 339818 hydrochloride is a K_V1.3 and K_V1.4 channel blocker¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

20 mM in DMSO. Centrifuge all product preparations before use (10000 x g for 1 min).

Up to four weeks at 4°C or three months at -20°C.

Natural peptide isolated from Dendroaspis angusticeps (Eastern green mamba).

10-500 nM.

α-Dendrotoxin inhibits 4-AP sensitive, inactivating voltage-gated K⁺ channels (K_V1.1, K_V1.2 and K_V1.6).

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

Natural peptide isolated from Dendroaspis angusticeps (Eastern green mamba).

10-500 nM.

β-Dendrotoxin inhibits 4-AP sensitive, inactivating voltage-gated K⁺ channels (K_V1.1, K_V1.2).

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

Natural peptide isolated from Dendroaspis angusticeps (Eastern green mamba).

10-100 nM.

γ-Dendrotoxin inhibits some voltage-gated K⁺ subtypes and reduces partially (slow) ⁸⁶Rb⁺ efflux from rat brain synaptosomes¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

Natural peptide isolated from Dendroaspis angusticeps (Eastern green mamba).

10-100 nM.

δ-Dendrotoxin inhibits 4-AP sensitive, inactivating voltage-gated K⁺ channels (K_V1.1, K_V1.2 and K_V1.6). In addition δ-Dendrotoxin inhibits ROMK1 channel currents.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

Natural peptide isolated from Dendroaspis polylepis polylepis (Black mamba).

10-100 nM.

Dendrotoxin-I is a highly selective blocker of voltage-gated K⁺ channels (K_V1.1 and K_V1.2), as well as heteromultimeric channels containing these, with other K_V1 isoforms¹. The inhibition effect is higher in Xenopus oocytes compared to mammalian cells².

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up one week at 4°C or three months at -20°C.

Natural peptide isolated from Dendroaspis polylepis polylepis (Black mamba).

100 nM

Dendrotoxin-K is a highly selective and potent blocker of voltage-gated K⁺ channels K_V1.1 and Kv1.1-containing heterooligomer.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer (pH 7.5). Centrifuge all product preparations before use (10000 x g 5 min).

One week at 4°C or six months at -20°C.

Synthetic peptide

1 nM - 1 μM.

Hemitoxin reversibly inhibits rat voltage-gated K⁺ channels K_V1.1 (KCNA1), K_V1.2 (KCNA2) and K_V1.3 (KCNA3)¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to one week at 4°C or three months at -20°C.

Synthetic peptide

0.1-0.2 pM.

Hongotoxin-1 is a potent selective inhibitor of K_V1.1, K_V1.2 and K_V1.3 voltage-gated K⁺ channels and a weak inhibitor of K_V1.6 K⁺ channel. Hongotoxin does not block K_V1.4 nor K_V1.5 currents¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

Synthetic peptide

1-100 pM.

HsTx1 Toxin is a highly potent K_V1.3 blocker¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any other aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to two weeks at 4°C or three months at -20°C.

Synthetic peptide

10-100 nM.

Kaliotoxin-1 is a potent inhibitor of large conductance Ca²⁺-activated K⁺ channels (BK_Ca)^1,2. Kaliotoxin-1 also binds the dendrotoxin sensitive voltage-dependent K⁺ channels (K_V1.1, K_V1.2 and K_V1.3 nM)³.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to one week at 4°C or three months at -20°C.

Synthetic peptide

50 pM - 50 nM.

Margatoxin is a blocker of K_V1.3 and K_V1.6 channels.

The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the products at -20°C. Protect from moisture.

Soluble in water. Centrifuge all product preparations before use (10000 x g, 5 min). For long-term storage in solution, we highly recommend preparing a stock solution in pure water (e.g., double-distilled water (ddH₂O) at a concentration between 100-1000x of the final working concentration. Divide the solution into small aliquots and store at -20°C. Upon use, thaw the relevant vial and dilute in your working buffer. The preparation of fresh solutions in working buffers before use is recommended. Avoid multiple freeze-thaw cycles to maintain biological activity. Centrifuge all product preparations before use (10000 x g, 5 min).

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Synthetic peptide

10 nM - 1 μM.

MCD peptide inhibits K_V1.1 and K_V1.2 channels^1,2.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or six months at -20°C.

Synthetic peptide

10-200 nM.

Noxiustoxin inhibits K_V1.2 and K_V1.3 K⁺ channels¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to two weeks at 4°C or three months at -20°C.

Synthetic peptide

5-100 nM.

OsK-1 inhibits K_V1.1, K_V1.2, K_V1.3 channels potently and K_Ca3.1 channel moderately¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer.

Up to one week at 4°C or three months at -20°C.

Synthetic peptide

10-200 nM.

Pandinotoxin Kα is an A-type and Shaker-related K⁺ channel blocker^1-4.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any other aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to two weeks at 4°C or three months at -20°C.

Synthetic peptide

1-100 nM.

Stichodactyla Toxin blocks K_V1.3, K_V1.1, K_V1.4, and K_V1.6 at subnanomolar concentrations and K_V3.2 channels at 1000-fold higher concentration than that required to inhibit K_V1.3 channels.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

Synthetic peptide

0.5 - 50 nM.

Tityustoxin-Kα blocks cloned K_V1.2 with high potency¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Any other aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).

Up to two weeks at 4°C or three months at -20°C.

1-200 µM.

Trimethylapigenin blocks K_V1.5 and hERG channels with IC₅₀ ~ 8 and 30 μM respectively. It also activates CFTR channels¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

50 mM in DMSO. Centrifuge all product preparations before use (10000 x g for 1 min).

Up to four weeks at 4°C or three months at -20°C.

200 nM - 200 µM.

UK-78282 hydrochloride blocks K_V1.3 and K_V1.4 in T lymphocytes¹.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

200 mM in DMSO. Centrifuge all product preparations before use (10000 x g for 1 min).

Up to four weeks at 4°C or three months at -20°C.