Overview
Alternative Name HT-2157
Lyophilized Powder yes
Source Synthetic
MW: 366.34
Purity: >98%
Effective concentration 10 nM – 10 µM.
Structure
Chemical name 1-phenyl-3-[3-(trifluoromethyl)phenyl]iminoindol-2-one.
Molecular formula C21H13F3N2O.
CAS No.: 303149-14-6
PubChem CID 1471834
Activity SNAP 37889 is a potent GalR3 galanin receptor antagonist, highly selective for GalR3 (Ki = 17.44 nM) over GalR1 and GalR2 (Ki > 10 µM), showing anxiolytic and antidepressant-like effects in rodent models in vivo1-2.
References-Activity
- Swanson, C.J. et al. (2005) Proc. Natl. Acad. Sci. U.S.A. 102, 17489.
- Konkel, MJ. et al. (2006) Bioorg. Med. Chem. Lett. 16, 3950.
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility Soluble in DMSO. Centrifuge all products before use (10000 x g 5 min).
Storage of solutions Up to three months at -20°C.
Our bioassay
Alomone Labs SNAP 37889 inhibits GalR2 receptor-mediated Ca2+ mobilization in CHO-K1-Gα16-mt-Aequorin cells.Dose-response of normalized SNAP 37889 (#S-210) inhibition of the galanin-evoked, GalR2 receptor-mediated Ca2+ mobilization, measured as aequorin-derived fluorescence following galanin application (IC50 = 7.57 µM).
Scientific background
SNAP 37889 is a potent and selective Galanin 3 receptor (GalR3) antagonist. The compound exists as E- and Z-isomers that interconvert quickly in solution at room temperature1,2.
Studies conducted in animals show that acute administration of SNAP 37889 enhances rat social interaction, reduces guinea pig vocalizations after maternal separation, and attenuates stress-induced hyperthermia in mice1.
Galanin is a widely distributed neuropeptide that regulates various endocrine, pain and cognitive functions, including learning and memory in the central nervous system (CNS). It activates one of three receptors belonging to the GPCR superfamily: GalR1, GalR2 and GalR3. GAL3 receptors are involved in anxiety, depression, and drug-seeking behavior1,2.
Target Galanin 3 receptor
Lyophilized Powder
For research purposes only, not for human use
Last Update: 07/05/2024
Specifications
Citations
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