Overview
SR 48527 (#S-225) is a highly pure, synthetic, and biologically active compound.
Alternative Name SR48527
Structure
For research purposes only, not for human use
Applications
Specifications
Properties
Technical Specifications
MW 549
Purity >95%
Molecular formula C29H29ClN4O5.
CAS No. 156579-04-3
Source Synthetic
PubChem CID 9915499
Chemical name (2S)-2-[[1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)pyrazole-3-carbonyl]amino]-2-cyclohexylacetic acid.
Biological Activity
Target Neurotensin Receptor 1
Effective concentration 1 nM – 1 µM.
Activity SR 48527, an analog of SR 48692, is a potent and selective antagonist of NTS1 receptors, shown to inhibit neurotensin-stimulated IP production with Ki of 24 nM1,2.
References
- Labbe-Jullie, C. et al. (1994) J. Pharmacol. Exp. Ther. 271, 267.
- Labbe-Jullie, C. et al. (1998) J. Biol. Chem. 273, 16351.
Solubility and Storage
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility Soluble in DMSO. Centrifuge all products before handling (10000 x g 5 min).
Storage of solutions Store at -20°C. It is recommended to aliquot stock solutions to prevent repeated thawing and freezing.
Scientific Background
References
Scientific background
SR 48527 is a potent and selective antagonist of neurotensin receptor 1 (NTR1/NTS1). It is an analog of SR 48692 and inhibits neurotensin-stimulated IP production with a Ki value of 24 nM1,2.
The two neurotensin receptors, NTR1 and NTR2, belong to the family of G-protein-coupled receptors1,2. The receptors are expressed in the brain and gastrointestinal tract where they play a role in pain transmission and intestinal motility.
References
- Labbe-Jullie, C. et al. (1994) J. Pharmacol. Exp. Ther. 271, 267.
- Labbe-Jullie, C. et al. (1998) J. Biol. Chem. 273, 16351.
Last Update: 08/01/2025
