Overview
Alomone Labs is pleased to offer the T-Type CaV Channel Basic Research Pack (#ESB-101). The Research Pack contains all you need for T-Type CaV research: Antibodies for each T-type CaV channel and specific T-type CaV blockers, all in one economical package!
Compounds
| Product Name | Cat # | Size |
|---|---|---|
| Antibodies | ||
Anti-CACNA1G (CaV3.1) Antibody |
ACC-021 | 1 x 0.2 ml |
CACNA1G/Cav3.1 Blocking Peptide |
BLP-CC021 | 1 x 40 µg |
Anti-CaV3.2 (CACNA1H) Antibody |
ACC-025 | 1 x 0.2 ml |
Cav3.2/CACNA1H Blocking Peptide |
BLP-CC025 | 1 x 40 µg |
Anti-CaV3.3 (CACNA1I) Antibody |
ACC-009 | 1 x 0.2 ml |
Cav3.3/CACNA1I Blocking Peptide |
BLP-CC009 | 1 x 40 µg |
| Blockers/Antagonists | ||
Mibefradil dihydrochloride hydrate |
M-150 | 1 x 10 mg |
ML 218 hydrochloride |
M-166 | 1 x 10 mg |
Scientific Background
T-type Ca2+ channels play an important role in many cellular processes such as hormone secretion, neurotransmitter release and cell differentiation.
T-type channels are also known to participate in the pacemaker activities of heart and neurons including thalamic neurons.1 Three genes encoding T-type Ca2+ channels have been cloned and designated as CaV3.1 (α1G), CaV3.2 (α1H) and CaV3.3 (α1I).1-3
While CaV3.1 (α1G) and CaV3.2 (α1H) are widely expressed in various tissues, CaV3.3 (α1I) is primarily expressed in the central nervous system, where high expression was described in thalamic neurons.
The Ca2+ current generated by the CaV3.3 channel displays much slower activation and inactivation compared to the currents produced by CaV3.1 and CaV3.2, suggesting it might play a different role in neuronal excitability.1,4
- Park, J.Y. et al. (2004) J. Biol. Chem. 279, 21707.
- Chemin, J. et al. (2001) Eur. J. Neurosci. 14, 1678.
- Monteil, A. et al. (2000) J. Biol. Chem. 275, 16530.
- Gomora, J.C. et al. (2002) Biophys. J. 83, 229.
