Overview
Alomone Labs is pleased to offer the T-Type CaV Channel Blocker Explorer Kit (#EK-111). The Explorer Kit contains many classical T-type CaV channel blockers, ideal for screening purposes.
Compounds
| Product Name | Cat # | Size |
|---|---|---|
L-Ascorbic acid |
L-140 | 1 x 10 g |
Benidipine hydrochloride |
B-120 | 1 x 5 mg |
GTx1-15 |
STT-300 | 1 x 50 µg |
Kurtoxin |
STK-800 | 1 x 25 µg |
Mibefradil dihydrochloride hydrate |
M-150 | 1 x 1 mg |
ML 218 |
M-165 | 1 x 5 mg |
ML 218 hydrochloride |
M-166 | 1 x 5 mg |
NNC 55-0396 dihydrochloride |
N-205 | 1 x 5 mg |
NNC 55-0396 dihydrochloride hydrate |
N-206 | 1 x 5 mg |
ProTx-I |
STP-400 | 1 x 0.1 mg |
ProTx-II |
STP-100 | 1 x 0.1 mg |
SKF 96365 hydrochloride |
S-175 | 1 x 5 mg |
TTA-A2 |
T-140 | 1 x 5 mg |
TTA-P2 |
T-155 | 1 x 5 mg |
Scientific Background
Voltage-dependent Ca2+ channels (CaV) form an important route for Ca2+ entry into cells upon deviations from the cell's resting membrane potential. There are ten CaV α1 subunit genes, divided into three subfamilies on both a functional and sequence homology basis. The CaV1 subfamily includes four genes which encode the L-type channels, the CaV3 subfamily includes three genes encoding the T-type channels and the CaV2 subfamily consists of three isoforms encoding P/Q- , N- and R-type channels, with all three contributing to neurotransmitter release in neurons.
- Catterall, W.A. et al. (2003) Pharmacol. Rev. 55, 579.
