Cat #: EK-111_KIT
Size: 14 Vials
Form: Lyophilized
L-Ascorbic acid Cat #: L-140
Size:
10 g
Source: Synthetic
MW: 176.1
Purity: >98%
Effective concentration
10 nM - 5 µM.
Activity
IC50 of 6.5 µM on T-type current of rat DRG neurons1. IC50s of 10 and 25 nM on cloned CaV3.2 channels from human and rat, respectively1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Water. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.
Benidipine hydrochloride Cat #: B-120
Size:
5 mg
Source: Synthetic
MW: 542
Purity: >99% (HPLC)
Effective concentration
1-100 µM.
Activity
Benidipine hydrochloride is a state-dependent Ca2+ channel blocker. It inhibits N-type and P/Q-type channels with IC50 of ~30 µM and is an order of magnitude more potent towards L-type channels, exhibiting the following IC50: 14 µM at -80mV and 5 µM at -60 mV holding potentials1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.
GTx1-15 Cat #: STT-300
Size:
50 µg
MW: 4074 Da
Purity: >98% (HPLC)
Net peptide content: 100%
Origin
Synthetic peptide
Effective concentration
200-500 nM.
Activity
GTx1-15 inhibits rat NaV1.3 and NaV1.7 voltage-gated Na+ channels as well as T-type Ca2+ channels.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Soluble in water. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to two weeks at 4°C or three months at -20°C.
Kurtoxin Cat #: STK-800
Size:
25 µg
MW: 7387 Da
Purity: >98% (HPLC)
Net peptide content: 100%
Origin
Synthetic peptide
Effective concentration
10-200 nM
Activity
Kurtoxin is a CaV3.1 and CaV3.2 channel blocker1,2.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Soluble in water. Centrifuge all products before use (10000 x g 5 min).
Storage after reconstitution
Store at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing.
Mibefradil dihydrochloride hydrate Cat #: M-150
Size:
1 mg
Source: Synthetic
MW: 568.55
Purity: >98%
Effective concentration
0.01-50 µM.
Activity
Mibefradil blocks T-type Ca2+ channels with an IC50 of ~1 µM. Orai1-3 and most potent on Orai32. It also modulates the gating properties of KV10.1 channel3.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
35 mM in water, 100 mM in DMSO. Centrifuge all product preparations before use (10 000 x g for 1 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.
ML 218 Cat #: M-165
Size:
5 mg
Source: Synthetic
MW: 369.3
Purity: >98%
Effective concentration
0.1-100 µM.
Activity
ML 218 is a blocker of T-type Ca2+ channels (IC50 values are 270 and 310 nM for CaV3.3 and CaV3.2 respectively)1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
25 mM in DMSO. Centrifuge all product preparations before use (10000 x g for 1 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.
ML 218 hydrochloride Cat #: M-166
Size:
5 mg
Source: Synthetic
MW: 405.8
Purity: >98%
Effective concentration
0.1-100 µM.
Activity
ML 218 is a blocker of T-type Ca2+ channels (IC50 values are 270 and 310 nM for CaV3.3 and CaV3.2 respectively)1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
100 mM in DMSO. Centrifuge all product preparations before use (10000 x g for 1 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.
NNC 55-0396 dihydrochloride Cat #: N-205
Size:
5 mg
Source: Synthetic
MW: 564.57
Purity: >95%
Effective concentration
1-100 µM.
Activity
NNC 55-0396 displays IC50 values of 6.8 and >100 μM for inhibition of CaV3.1 T-type channels and HVA currents respectively in INS-1 cells1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
50 mM in water. Centrifuge all product preparations before use (10000 x g for 1 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.
NNC 55-0396 dihydrochloride hydrate Cat #: N-206
Size:
5 mg
Source: Synthetic
MW: 573.48
Purity: >99.5%
Effective concentration
1-100 µM.
Activity
NNC 55-0396 displays IC50 values of 6.8 and >100 μM for inhibition of CaV3.1 T-type channels and HVA currents respectively in INS-1 cells1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
50 mM in water. Centrifuge all product preparations before use (10000 x g for 1 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.
ProTx-I Cat #: STP-400
Size:
0.1 mg
MW: 3988 Da
Purity: >98% (HPLC)
Net peptide content: 100%
Origin
Synthetic peptide
Effective concentration
10-100 nM.
Activity
ProTx-I inhibits voltage-gated Ca2+ (CaV3.1), K+ (KV2.1), and all Na+ channels tested (NaV1.2, NaV1.5, NaV1.7 and NaV1.8). The toxin shifts the voltage-dependence of channel activation to more positive potentials.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to two weeks at 4°C or three months at -20°C.
ProTx-II Cat #: STP-100
Size:
0.1 mg
MW: 3826.6 Da
Purity: >98% (HPLC)
Net peptide content: 100%
Origin
Synthetic peptide
Effective concentration
10-500 nM.
Activity
ProTx-II inhibits NaV channels1. ProTx-II could also modulate T-type Ca2+ channels at higher concentrations2.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any aqueous buffer. Centrifuge all product preparations before use (1000 X g 5 min).
Storage after reconstitution
Up to one week at 4°C or three months at -20°C.
SKF 96365 hydrochloride Cat #: S-175
Size:
5 mg
Source: Synthetic
MW: 402.9
Purity: >98%
Effective concentration
1-100 µM.
Activity
SKF 96365 is an Inhibitor of TRPC channels and inhibitor of T-type calcium channels with an IC50 560 nM for CaV3.1 channels1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
100 mM in H2O. Centrifuge all product preparations before use (10 000 x g for 1 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.
TTA-A2 Cat #: T-140
Size:
5 mg
Source: Synthetic
MW: 378.39
Purity: >99%
Effective concentration
0.05-100 µM.
Activity
TTA-A2 blocks T-type CaV channels with an IC50 of ~100 nM (at -100 mV holding potential) and ~5 µM (at holding potential -80 mV).
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
100mM in DMSO. Centrifuge all product preparations before use (10000 x g for 1 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.
TTA-P2 Cat #: T-155
Size:
5 mg
Source: Synthetic
MW: 431
Purity: >96% (HPLC)
Effective concentration
0.05-10 µM.
Activity
TTA-P2 blocks T-type currents in DRGs with IC50 of 100 nM and 22 nM in thalamocortical and reticular neurons1,2.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Up to 25mM in DMSO. Centrifuge all product preparations before use (10000 x g for 1 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.
For more information, please refer to individual certificate of analysis for each product.
For research purposes only, not for human use
