Overview
Alternative Name 2-Aminoethylsulfonic acid, Tauphon
Lyophilized Powder yes
Source Synthetic
MW: 125.15
Purity: >99%
Effective concentration 0.05-5 mM.
Structure
Chemical name 2-aminoethanesulfonic acid.
Molecular formula C2H7NO3S.
CAS No.: 107-35-7
PubChem CID 1123
Activity Taurine is a Glycine receptor (GlyR) partial agonist (EC50=1.7 mM)1. It displaces [3H]Strychnine bound to GlyR α1 expressing 293 cells membrane fraction (Ki=170 µM)2.
References-Activity
- Schmieden, V. et al. (1999) Mol. Pharmacol. 56, 464.
- Rajendra, S. et al. (1995) EMBO J. 14, 2987.
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility >100mM in H2O. Centrifuge all product preparations before use (10000 x g 5 min).
Storage of solutions Up to four weeks at 4°C or three months at -20°C.
Our bioassay
Alomone Labs Taurine inhibits specific binding of Strychnine to rat spinal cord Strychnine-sensitive Glycine receptors.Percent inhibition of specific binding of 10 nM [3H]Strychnine to membranes from rat spinal cord was plotted against concentrations of Taurine (#T-130), (green circles) and of (-)-Strychnine (assay standard, black squares) and used to calculate IC50 and Ki values for Taurine (IC50 ≈ 397 µM, and Ki ≈ 224 µM).
Scientific background
Taurine (2-aminoethanesulfonic acid) is a β-amino acid, one of the most abundant free amino acids found in vertebrates. Taurine can be present in many tissues including brain, myocardium, and kidney. It plays an important role in several physiological processes including cardiac contraction, antioxidation, blunting of hypertension, bile acid conjugation, maintenance of calcium homeostasis, osmoregulation, and membrane stabilization.
Taurine acts as an endogenous partial agonist at the inhibitory glycine receptor (GlyR)1,2.
The glycine receptor is a member of the ligand-gated ion channel (LGIC) superfamily. The receptor mediates fast inhibitory neurotransmission in the mammalian spinal cord and parts of the brain3.
Target Glycine receptor, Taurine transporter
Lyophilized Powder
For research purposes only, not for human use
Last Update: 07/05/2024
Specifications
Citations
Citations
