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Overview
Alternative Name TTX
Structure
Scientific background Tetrodotoxin (TTX) is an established potent and selective blocker of some NaV channels.1 Moreover, TTX sensitivity is used to define subclasses of NaV channels.2 It is widely used both to probe NaV activity and to reduce or block excitability in neurophysiological preparations.
For research purposes only, not for human use
Specifications
Applications
Our Bioassay
Our bioassay
Alomone Labs Tetrodotoxin citrate free inhibits native NaV currents in PC12 and ND7-23 cells.Tetrodotoxin citrate free (#T-500) inhibits PC12 (top) and ND7-23 (bottom) cells at a concentration of 60 nM. Left graphs show the time course of inward current amplitude upon bath application (marked by the horizontal bars) and wash of TTX. Membrane potential was clamped to -120 mV and currents were elicited by 20 ms test pulses to -10 or -20 mV (upper and lower graphs respectively), delivered every 10 sec. Right graphs show the superimposed traces of control current (red) and during perfusion of TTX (black).
Last Update: 08/01/2025
