Overview
Cat #:
Size:
10 mg
Lot:
T160SM0110
Alternative Name Hycamtin, Topotecan lactone
Lyophilized Powder yes
Source Synthetic
MW: 457.9
Purity: 99%.
Effective concentration 10-200 µM.
Structure
Chemical name 9-Dimethylaminomethyl-10-hydroxycamptothecin.
Molecular formula C23H24ClN3O5.
CAS No.: 119413-54-6
PubChem CID 60699
Activity Topotecan is a 5-HT3A receptor antagonist1.
References-Activity
- Nakamura, Y. et al. (2013) J. Neurochem. 125, 7.
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage of solutions Up to four weeks at 4°C or three months at -20°C.
Our bioassay
- Alomone Labs Topotecan hydrochloride blocks 5-HT3A receptors expressed in HEK 293T cells.5-HT3A receptor currents were elicited by 10 µM 5-HT, delivered every 3 minutes. Topotecan hydrochloride (#T-160) was applied 30 seconds before stimulation at 10, 100 and 200 µM as indicated and completely inhibited the 5-HT induced current in a dose dependent and reversible manner.
Target 5-HT3A/B receptors
Lyophilized Powder
For research purposes only, not for human use
Last Update: 30/03/2021
Specifications
Citations
Citations