Name: Trimethylapigenin
Brand: Alomone Labs
SKU: T-145

Overview

Cat #: T-145

Lyophilized Powder yes

Source Synthetic

MW: 312.3

Purity: >96%

Form Lyophilized powder.

Effective concentration 1-200 µM.

Structure

Chemical name 5,7-dimethoxy-2-(4-methoxyphenyl)chromen-4-one.

Molecular formula C₁₈H₁₆O₅.

CAS No.: 5631-70-9

Activity Trimethylapigenin blocks K_V1.5 and hERG channels with IC₅₀~ 8 and 30 μM respectively. It also activates CFTR channels¹.

Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Solubility 50 mM in DMSO. Centrifuge all product preparations before use (10000 x g for 1 min).

Storage of solutions Up to four weeks at 4°C or three months at -20°C.

Our bioassay

Alomone Labs Trimethylapigenin inhibits K_V1.5 channels expressed in Xenopus oocytes.
A. Time course of K_V1.5 plateau current amplitude elicited by 150 ms voltage step from holding potential of -80 mV to +50 mV, delivered every 10 seconds. Application of 150 µM Trimethylapigenin (#T-145) inhibits K_V1.5 currents in a reversible manner (indicated by the horizontal bar). B. Representative current traces before and during application of 150 µM Trimethylapigenin as indicated.

References - Scientific background

Liu, Y. et. al. (2012) Biochem. Pharmacol. 84, 498.

Scientific background

Trimethylapigenin is a natural flavone and a fully methylated derivate of apigenin, present in citrus, kaempferia parviflora, etc. Trimethylapigenin inhibits cardiac potassium currents. This compound blocks K_V1.5 current in HEK 293 cell line (IC₅₀ = 6.4 μM), and the ultra-rapid delayed rectify K⁺ current (I_Kur) in human atrial myocytes (IC₅₀ = 8.0 μM) by binding to the open channels. In addition, trimethylapigenin decreased transient outward K⁺ current (I_to) in human atrial myocytes, inhibited acetylcholine-activated K⁺ current (IC₅₀ = 6.8 μM) in rat atrial myocytes¹.

It has been demonstrated that trimethylapigenin is effective in modulating bacterial drug resistance, and in α-glycosidase inhibition, anti-adipogenesis, anti-carcinoma, anti-inflammation, and chemoprevention. In addition, trimethylapigenin has been found to activate CFTR Cl⁻ channels¹.

Target K_V1.5, K_V11.1, CFTR channels

Lyophilized Powder

Trimethylapigenin (#T-145) is a highly pure, synthetic, and biologically active compound.

Certificate of Analysis SDS

For research purposes only, not for human use

Last Update: 07/05/2024

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Trimethylapigenin

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Scientific Background

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