Overview
Alomone Labs is pleased to offer the TRPM8 Channel Basic Research Pack (#ESB-301). The Research Pack contains all you need for TRPM8 research: An antibody that specifically recognizes an extracellular domain of the TRPM8 channel protein and TRPM8 channel blockers and activators, all in one economical package!
Compounds
| Product Name | Cat # | Size |
|---|---|---|
| Antibodies | ||
Anti-TRPM8 (extracellular) Antibody |
ACC-049 | 1 x 0.2 ml |
TRPM8 (extracellular) Blocking Peptide |
BLP-CC049 | 1 x 40 µg |
| Activators/Agonists | ||
Icilin |
I-145 | 1 x 25 mg |
WS 12 |
W-105 | 1 x 10 mg |
| Blockers/Antagonists | ||
M8-B hydrochloride |
M-220 | 1 x 10 mg |
TC-I 2014 |
T-200 | 1 x 10 mg |
Scientific Background
The TRPM8 channel is the cold and menthol receptor activated by either cold temperatures(~28°C) or menthol.1
TRPM8 is expressed in dorsal root ganglia (DRGs) where about 5%-10% of the small diameter DRG neurons express the channel.2,3 In DRGs, TRPM8 expressing neurons do not express the TRPV1 channel.4 Overexpression of TRPM8 was found in prostate cancer cells. However, the physiological and pathological roles that these cells play is still elusive.5 In prostate, it was suggested that TRPM8 might play a possible role in the progression of cancer to the metastatic stage.5
- Brauchi, S. et al. (2004) Proc. Natl. Acad. Sci. 101, 15494.
- McKemy, D.D. et al. (2002) Nature 416, 52.
- Peier, A.M. et al. (2002) Cell 108, 705.
- Dragoni, I. et al. (2006) J. Biol. Chem. 281, 37353.
- Zhang, L. et al. (2006) Endocr. Relat. Cancer 13, 27.
