Cat #: EK-152_KIT
Size: 11 Vials
Form: Lyophilized
AMG-9090 Cat #: A-300
Size:
5 mg
Source: Synthetic
MW: 395.12
Purity: >98%
Effective concentration
50 nM - 50 µM.
Activity
AMG-9090 is TRPA1 channel blocker, shown to potently and concentration-dependently inhibit AITC-induced increase in intracellular calcium mediated by human TRPA1 (IC50 = 21 nM)1,2. The compound also possesses inhibitory effects on human TRPM8 and TRPV1 channels1,2.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C. Protect from light.
Reconstitution
Up to 50 mM in DMSO. Centrifuge all products before use (10000 x g 5 min).
Storage after reconstitution
Up to three months at -20°C.
AMTB hydrochloride Cat #: A-305
Size:
5 mg
Source: Synthetic
MW: 430.99
Purity: >97%
Effective concentration
1-100 µM.
Activity
AMTB hydrochloride is a TRPM8 channel blocker, inhibiting icilin-induced human TRPM8 channel activation (pIC50 = 6.23), selective over TRPV1 and TRPV41.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored desiccated at -20°C.
Reconstitution
Up to 100 mM in DMSO. Centrifuge all products before use (10000 x g 5 min).
Storage after reconstitution
Up to three months at -20°C.
AMG2850 Cat #: A-340
Size:
5 mg
Source: Synthetic
MW: 417.35
Purity: >99% (HPLC)
Effective concentration
0.1-10 µM.
Activity
AMG2850 is a potent and selective blocker of TRPM8 channels. It was shown in vitro to inhibit rat TRPM8 cold, menthol and icilin activation with IC50 of 7.3 nM, 156 nM and 204 nM, respectively. Highly selective for TRPM8 over TRPV1 and TRPA1 channels and orally bioavailable (Fpo>40%)1,2.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Up to 200 mM in DMSO. Centrifuge all products before use (10000 x g 5 min).
Storage after reconstitution
Up to three months at -20°C.
D-3263 hydrochloride Cat #: D-195
Size:
5 mg
Source: Synthetic
MW: 409.95
Purity: >97%
Effective concentration
1 nM – 10 µM.
Activity
D-3263 hydrochloride is a potent TRPM8 channel agonist1.
It shows evidence of activity in preclinical tumor models and was tested in phase 1 clinical trials for the treatment of prostate cancer1-3.
It shows evidence of activity in preclinical tumor models and was tested in phase 1 clinical trials for the treatment of prostate cancer1-3.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Up to 100 mM in DMSO. Centrifuge all products before use (10000 x g 5 min).
Storage after reconstitution
Up to three months at -20°C.
Frescolat MGA Cat #: F-165
Size:
1 g
Source: Synthetic
MW: 228.33
Purity: >97%
Effective concentration
0.1-10 µM.
Activity
Frescolat MGA is a TRPM8 channel activator and cooling agent. It activates mouse TRPM8 channels with EC50 of 4.8 µM1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C. Store in a cool and dry place.
Reconstitution
Up to 200 mM in DMSO. Centrifuge all products before use (10000 x g 5 min).
Storage after reconstitution
Up to three months at -20°C.
Icilin Cat #: I-145
Size:
5 mg
Source: Synthetic
MW: 311.29
Purity: >95%
Effective concentration
1 nM – 1 µM.
Activity
Icilin is a potent TRPM8 channel activator (EC50 = 0.2 µM)1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Up to 100 mM in DMSO. Centrifuge all products before use (10000 x g 5 min).
Storage after reconstitution
Up to three months at -20°C.
M8-B hydrochloride Cat #: M-220
Size:
5 mg
Source: Synthetic
MW: 432.96
Purity: >99%
Effective concentration
10 nM - 10 µM.
Activity
M8-B hydrochloride is a potent and selective blocker of TRPM8 channel, inhibiting rat and human TRPM8 activation by cold, by icilin and by menthol with IC50 values of 7.8 nM, 26.9 nM and 64.3 nM, respectively, whilst having little or no effect on other TRP channels (IC50 > 20 μM)1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored desiccated at +4°C.
Reconstitution
Up to 100 mM in DMSO. Centrifuge all products before use (10000 x g 5 min).
Storage after reconstitution
Up to three months at -20°C.
RQ 00203078 Cat #: R-170
Size:
5 mg
Source: Synthetic
MW: 554.84
Purity: >99%
Effective concentration
1 nM – 1 µM.
Activity
RQ 00203078 is a potent and selective TRPM8 antagonist, shown to inhibit menthol-evoked human and rat TRPM8-mediated calcium influx with IC50 of 8.3 nM and 5.8 nM, respectively, while being highly selective over hTRPV4, h/rTRPV1, h/rTRPA1 and TRPM21,2.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at +4°C.
Reconstitution
Up to 100 mM in DMSO. Centrifuge all products before use (10000 x g 5 min).
Storage after reconstitution
Up to three months at -20°C.
TC-I 2014 Cat #: T-200
Size:
5 mg
Source: Synthetic
MW: 467.41
Purity: >96%
Effective concentration
1 nM – 1 µM.
Activity
TC-I 2014 is a potent and selective TRPM8 blocker, inhibiting canine, rat, and human TRPM8-mediated Ca2+ influx with IC50 values of 0.8, 4.0, and 3.0 nM, respectively1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at +4°C.
Reconstitution
Up to 100 mM in DMSO. Centrifuge all products before use (10000 x g 5 min).
Storage after reconstitution
Up to three months at -20°C.
WS 3 Cat #: W-100
Size:
1 g
Source: Synthetic
MW: 211.34
Purity: >98%
Effective concentration
0.1-10 µM.
Activity
WS 3 is a TRPM8 channel activator (EC50 = 3.7 μM)1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Up to 100mM in DMSO. Centrifuge all products before use (10000 x g 5 min).
Storage after reconstitution
Up to three months at -20°C.
WS 12 Cat #: W-105
Size:
5 mg
Source: Synthetic
MW: 289.41
Purity: >99%
Effective concentration
1 nM – 10 µM.
Activity
WS 12 is a TRPM8 channel activator (EC50 = 193 nM)1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Up to 75 mM in Ethanol. Centrifuge all products before use (10000 x g 5 min).
Storage after reconstitution
Up to three months at -20°C.
For more information, please refer to individual certificate of analysis for each product.
For research purposes only, not for human use
