Overview
Alomone Labs is pleased to offer the TRPV1 Channel Basic Research Pack (#ESB-300). The Research Pack contains all you need for TRPV1 research: Antibodies recognizing different domains of the channel, specific TRPV1 blockers and an activator, all in one economical package!
Compounds
| Product Name | Cat # | Size |
|---|---|---|
| Antibodies | ||
Anti-TRPV1 (VR1) Antibody |
ACC-030 | 1 x 0.2 ml |
TRPV1/VR1 Blocking Peptide |
BLP-CC030 | 1 x 40 µg |
Anti-TRPV1 (VR1) (extracellular) Antibody |
ACC-029 | 1 x 0.2 ml |
TRPV1/VR1 (extracellular) Blocking Peptide |
BLP-CC029 | 1 x 40 µg |
| Activators/Agonists | ||
Capsaicin |
C-125 | 1 x 250 mg |
| Blockers/Antagonists | ||
AMG 9810 |
A-180_10 mg | 1 x 10 mg |
SB-366791 |
S-180 | 1 x 25 mg |
Scientific Background
TRPV1 (also named VR1, capsaicin receptor and vanilloid receptor) is a member of the transient receptor potential (TRP) channel family, which includes TRPC, TRPM, TRPA, TRPP, TRPML and the TRPV subfamilies. The TRPV subfamily consists of six members named, TRPV1-6. The TRPV1 channel is a vanilloid gated, nonselective cation channel.
The channel has sequence homology to the TRP family, and shares a similar predicted structure of six transmembrane domain (TM) with a pore loop between TM5 and TM6.1 TRPV1 is expressed predominantly in nociceptors and in sensory neurons.2,3
TRPV1 has many activators among them heat, protons, vanilloids like capsaicin, resiniferatoxin (RTX), and lipids. This channel is associated with tissue injury and inflammation.5,6
- Gunthorpe, M.J. et al. (2002) Trends Pharmacol. Sci. 23, 183.
- Cesare, P. et al. (1999) Proc. Natl. Acad. Sci. U.S.A. 96, 7658.
- Kim, J. et al. (2003) Nature 424, 81.
- Ahern, G. P. et al. (2003) J. Biol. Chem. 278, 30429.
- Ross, R.A. et al. (2003) Br. J. Pharmacol. 140, 790.
- Tominaga, M. et al. (1998) Neuron 21, 531.
