Overview
Lyophilized Powder yes
Source Synthetic
MW: 431
Purity: >99%
Form Lyophilized powder.
Effective concentration 0.05-10 µM.
Structure
Chemical name (S)-3,5-Dichloro-N-((1-((2,2-dimethyltetrahydro-2H-pyran-4-yl)methyl)-4-fluoropiperidin-4-yl)methyl)benzamide.
Molecular formula C21H29Cl2FN2O2.
CAS No.: 1072018-68-8
PubChem CID 24893979
Activity TTA-P2 blocks T-type currents in DRGs with IC50 of 100 nM and 22 nM in thalamocortical and reticular neurons1,2.
References-Activity
- Choe, W. et al. (2011) Mol. Pharmacol. 80, 900.
- Dreyfus, F.M. et al. (2010) J. Neurosci. 30, 99.
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility 50 mM in DMSO. Centrifuge all product preparations before use (10,000 x g for 1 min).
Storage of solutions Up to four weeks at 4°C or three months at -20°C.
Our bioassay
Alomone Labs TTA-P2 (S-enantiomer) blocks T-type CaV channels expressed in Xenopus oocytes.A. Time course of CaV3.2 peak current amplitude, elicited by 100 ms voltage step from holding potential of -100 mV to -30 mV, delivered every 10 seconds. Application of 5 µM TTA-P2 (S-enantiomer) (#T-210) inhibits the CaV3.2 current in a reversible manner (indicated by the horizontal bar). B. Representative current traces before and during application of 5 µM TTA-P2 as indicated.
Scientific background
TTA-P2 is a novel, potent and selective T-type CaV channel blocker. In thalamocortical and reticular neurons, it blocks T-type currents with an IC50 of 22 nM without affecting high voltage Ca2+ channels1. In rat DRGs, it blocks T-type currents with an IC50 of 100 nM and stabilizes the channel in the inactive state2.
TTA-P2 has the potential of acting as an antinociceptive agent2.
Target CaV3 channels
Lyophilized Powder
For research purposes only, not for human use
Last Update: 07/05/2024
Specifications
Citations
Citations
