Overview
Alomone Labs is pleased to offer the TTX-Sensitive NaV Channel Blocker Explorer Kit (#EK-105). This Explorer Kit includes both classical and novel NaV blockers, ideal for screening purposes.
Compounds
| Product Name | Cat # | Size |
|---|---|---|
µ-Conotoxin KIIIA |
C-280 | 1 x 0.1 mg |
Ceratotoxin-2 |
STC-100 | 1 x 50 µg |
µ-Conotoxin PIIIA |
STC-400 | 1 x 0.1 mg |
Huwentoxin-IV |
STH-100 | 1 x 0.1 mg |
Pilsicainide hydrochloride |
P-145 | 1 x 5 mg |
Pterinotoxin-1 |
STT-100 | 1 x 0.1 mg |
Phrixotoxin-3 |
STP-720 | 1 x 0.1 mg |
QX-314 chloride |
Q-150 | 1 x 50 mg |
Ralfinamide mesylate |
R-105 | 1 x 5 mg |
Tetrodotoxin citrate |
T-550 | 1 x 50 µg |
Scientific Background
Voltage-gated sodium channels (NaV) are essential for the generation of action potentials and for cell excitability.1 NaV channels are activated in response to depolarization and selectively allow thr flow of Na+ ions.
To date, nine NaV α subunits have been cloned and named NaV1.1-NaV1.9.4-5 The NaV channels are classified into two groups according to their sensitivity to Tetrodotoxin (TTX): TTX-sensitive (NaV1.1, NaV1.2, NaV1.3, NaV1.4, NaV1.6 and NaV1.7) and TTX-resistant (NaV1.5, NaV1.8 and NaV1.9).2-3 Mammalian sodium channels are heterotrimers, composed of a central, pore-forming α subunit and two auxiliary β subunits. The expression of the α subunit isoform is developmentally regulated and tissue specific.
