Overview
Lyophilized Powder yes
Origin Natural peptide isolated from Dendroaspis angusticeps (Eastern green mamba).
MW: ~7000 Da
Purity: >98% (HPLC)
Effective concentration 10-100 nM.
Activity γ-Dendrotoxin inhibits some voltage-gated K+ subtypes and reduces partially (slow) 86Rb+ efflux from rat brain synaptosomes1.
References-Activity
- Benishin, C.G. et al. (1988) Mol. Pharmacol. 34, 152.
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage of solutions Up to four weeks at 4°C or three months at -20°C.
Our bioassay
Alomone Labs γ-Dendrotoxin inhibits cloned KV1.1 and KV1.2 channel currents heterologously expressed in Xenopus oocytes.KV1.1 (left, in 2 mM K+) and KV1.2 (right, in 5 mM K+) channels currents, elicited by 200 ms depolarization from holding potential of -100 mV to +20 mV, before and during application of 100 nM γ-Dendrotoxin (#D-370). 80% (n = 4) of the KV1.1 and 21% (n = 4) of the KV1.2 channels were inhibited by 100 nM γ-Dendrotoxin, respectively.
References - Scientific background
- Harvey, A.L. and Anderson, A.J. (1985) Pharmacol. Ther. 31, 33.
- Benishin, C.G. et al. (1988) Mol. Pharmacol. 34, 152.
Scientific background γ-Dendrotoxin is isolated from Dendroaspis angusticeps snake venom by modification of the procedures of Harvey1 and Benishin2 and purified to homogeneity.
Target KV1.1, KV1.2 K+ channels
Peptide Content: 100%
Lyophilized Powder
γ-Dendrotoxin (#D-370) is a highly pure, natural, and biologically active peptide toxin.
For research purposes only, not for human use
Last Update: 07/05/2024
Applications
Citations
Citations
Powered by BiozProduct citations
- Southan, A.P. and Robertson, B. (2000) J. Neurosci. 20, 114.
- Southan, A.P. and Robertson, B. (1998) Br. J. Pharmacol. 125, 1375.
- Owen, D.G. et al. (1997) Br. J. Pharmacol. 120, 1029.
